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Related Experiment Video

Updated: Apr 28, 2026

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells
03:45

Author Spotlight: Advancing Tissue Regeneration and Disease Modeling with Dental Pulp Stem Cells

Published on: May 5, 2023

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Tissue engineering in dentistry.

Ensanya Ali Abou Neel1, Wojciech Chrzanowski2, Vehid M Salih3

  • 1Division of Biomaterials, Operative and Aesthetic Department Biomaterials Division, King Abdulaziz University, Jeddah, Saudi Arabia; Biomaterials Department, Faculty of Dentistry, Tanta University, Tanta, Egypt; UCL Eastman Dental Institute, Biomaterials & Tissue Engineering, 256 Gray's Inn Road, London WC1X 8LD, UK.

Journal of Dentistry
|June 1, 2014
PubMed
Summary

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Tissue engineering offers promising advancements for dental applications, particularly in managing periodontal diseases and exploring stem cell-based therapies. However, challenges remain in predictably reconstructing complex dental structures and ensuring clinical safety.

Area of Science:

  • Biomaterials Science
  • Regenerative Medicine
  • Dental Research

Background:

  • Craniofacial tissue loss necessitates innovative reconstructive approaches.
  • Tissue engineering has emerged as a key strategy for addressing these deficits.
  • Significant research has focused on dental applications, including stem cells and guided tissue regeneration.

Purpose of the Study:

  • To provide practitioners with updated information on tissue engineering in dentistry.
  • To review potential applications of tissue engineering for dental and craniofacial reconstruction.
  • To highlight current challenges and future directions in the field.

Main Methods:

  • A comprehensive literature search was conducted using "PUBMED".
  • Keywords included "tissue engineering", "dentistry", "dental stem cells", and "guided tissue regeneration".
Keywords:
Bioengineered teethBiomimetic scaffoldsDentine-pulp complexTissue engineering strategies

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  • Articles were selected based on their relevance to tissue engineering in dentistry.

    • Main Results:

    • Guided tissue engineering methods show promise for periodontal disease management.
    • Predictable reconstruction of whole teeth and periodontal structures remains a significant challenge.
    • Limited progress has been made in developing reproducible and clinically safe oral tissue repair approaches.

    Conclusions:

    • Despite challenges, the future of dental tissue engineering, especially with stem cells, is promising.
    • Further research is needed for clinically safe and reproducible oral tissue regeneration.
    • Ethical considerations regarding stem cell therapies require careful assessment.