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Updated: Apr 28, 2026

Optimization of Radiochemical Reactions using Droplet Arrays
Published on: February 12, 2021
Optimizing the transfer of [¹⁸F]fluoride from aqueous to organic solvents by electrodeposition using carbon
Fabian Kügler1, Daniel Roehrens1, Milosch Stumpf1
1Institute of Neuroscience and Medicine, INM-5: Nuclear Chemistry, Forschungszentrum Jülich GmbH, 52425 Jülich, Germany.
Abstract:
The effect of varying structural modifications of carbon anodes, ranging from thin layers of crystalline boron-doped diamond up to highly graphitic bulk materials, was systematically examined for the possibility of electrochemical fixation and desorption of no-carrier-added [(18)F]fluoride from an aqueous solution. Pyrolysed carbon, i.e. "glassy carbon" (Sigradur(®)G), proved as the most efficient material for deposition and release. An overall radiochemical yield of about 60% was achieved when using this for fixation and DMSO/ionic additive as organic solution for the release of [(18)F]fluoride.
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