Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Cystic Fibrosis: Pathogenesis

Cystic Fibrosis: Pathogenesis

Cystic fibrosis (CF), an autosomal recessive disorder, significantly affects the function of exocrine glands. This genetically inherited disease is characterized by the production of thick and sticky mucus, which can severely affect various organs and systems in the body.
CF is primarily caused by a genetic mutation in a chromosome 7 gene coding for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. The most common gene mutation leading to CF is the ΔF508 mutation,...

Cystic Fibrosis: Management

Cystic Fibrosis: Management

Cystic fibrosis (CF) is an autosomal recessive disorder that predominantly affects individuals of Northern European descent, occurring at a rate of 1 in 3500. It is caused by a genetic mutation in a gene on chromosome 7, most commonly the ΔF508 mutation, that codes for the cystic fibrosis transmembrane conductance regulator (CFTR) protein. This results in thicker mucus secretions and obstruction pathologies in multiple organs, including the lungs and sinuses.
Sinus disease and chronic...

Serum Laboratory Studies, Stool Test, Breath Test

Serum Laboratory Studies, Stool Test, Breath Test

Gastrointestinal (GI) diagnostic studies are pivotal in confirming, ruling out, diagnosing, or staging various diseases, including cancers. Following diagnosis, allocating time for discussions with the patient and providing informational resources is crucial. Diagnostic assessments of the GI tract often occur in outpatient settings like endoscopy suites or GI labs. Preparation for these tests may include dietary restrictions, fasting, liquid bowel preparations, laxatives, enemas, and the...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Image processing and AI techniques for climate change detection using remote sensing: a comprehensive review.

Frontiers in artificial intelligence·2026

Same author

Normal SFLC Ratio in Newly Diagnosed Myeloma: A Potential Biomarker of Non-High-Risk and Nonaggressive Disease.

International journal of laboratory hematology·2026

Same author

Indolent Tumour of the Upper Lip: A Case of Lobulated Acinic Cell Carcinoma.

Cureus·2025

Same author

Complement-independent pathogenic influences of anti-HMGCR + and anti-SRP + immune-mediated necrotizing myopathy autoantibodies on engineered muscle function.

Skeletal muscle·2025

Same author

Prevalence of IDH1/IDH2 Mutations in Adult Indian Acute Myeloid Leukaemia Patients and Their Impact on Outcome.

Indian journal of hematology & blood transfusion : an official journal of Indian Society of Hematology and Blood Transfusion·2025

Same author

A constricted mitochondrial morphology formed during respiration.

Nature communications·2025

Search research articles

Related Experiment Video

Updated: Apr 28, 2026

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

Cystic fibrosis: need for mass deployable screening methods.

Aditya Singh Sengar¹, Anirudh Agarwal, Manish K Singh

¹Department of Electronics and Communication, The LNM Institute of Information Technology, Jaipur, 302031, India, a.sengar.bkn@gmail.com.

Applied Biochemistry and Biotechnology

|June 2, 2014

Summary

This summary is machine-generated.

Cystic fibrosis (CF) is a genetic disorder impacting multiple organs due to cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations. This review highlights advancements in CF diagnosis and suggests future research directions.

More Related Videos

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

Related Experiment Videos

Last Updated: Apr 28, 2026

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Generation of Human Nasal Epithelial Cell Spheroids for Individualized Cystic Fibrosis Transmembrane Conductance Regulator Study

Published on: April 11, 2018

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Rectal Organoid Morphology Analysis ROMA: A Diagnostic Assay in Cystic Fibrosis

Published on: June 10, 2022

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Implementation of Non-invasive Point of Care Transient Elastography for Evaluation of Liver Disease in Pediatric Populations with Cystic Fibrosis

Published on: August 29, 2025

Area of Science:

Medical Genetics
Molecular Biology
Pulmonology

Background:

Cystic fibrosis (CF) is an autosomal recessive disease stemming from mutations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene.
CFTR protein functions as an ATP-binding cassette superfamily member and a critical chloride channel, regulating epithelial cell function across various organ systems.
CF impacts the airways, gastrointestinal tract, exocrine glands, and genitourinary system, leading to severe chronic pulmonary disorders and other systemic complications.

Purpose of the Study:

To review and summarize the current state-of-the-art diagnostic methods for cystic fibrosis.
To identify and propose novel research domains for advancing cystic fibrosis diagnosis based on existing literature.

Main Methods:

Comprehensive literature review of published cystic fibrosis research.
Analysis of recent advancements in diagnostic techniques for CF.

Main Results:

The review synthesizes current knowledge on CF diagnostic approaches.
Identified gaps and opportunities for future research in CF diagnostics.

Conclusions:

Accurate and timely diagnosis of cystic fibrosis is crucial for managing its complex clinical manifestations.
Further research into novel diagnostic strategies is warranted to improve patient outcomes and disease management.