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Photodynamic therapy for psoriasis.

Young M Choi1, Lily Adelzadeh, Jashin J Wu

  • 1David Geffen School of Medicine , UCLA, Los Angeles, CA , USA and.

The Journal of Dermatological Treatment
|June 3, 2014
PubMed
Summary
This summary is machine-generated.

Topical aminolevulinic acid photodynamic therapy (ALA-PDT) for psoriasis is not effective due to inconsistent results and severe pain. Alternative photosensitizers show more promise for psoriasis treatment.

Keywords:
ALAPpIXaminolevulinic acidhypericinmethylene blueverteporfin

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Area of Science:

  • Dermatology
  • Photomedicine

Background:

  • Photodynamic therapy (PDT) using aminolevulinic acid (ALA-PDT) initially showed promise for psoriasis treatment in the 1990s.
  • Early studies reported plaque clearance following topical ALA-PDT.

Purpose of the Study:

  • To systematically review the efficacy and tolerability of topical ALA-PDT for chronic plaque psoriasis.
  • To explore alternative photosensitizers and light therapy modalities for psoriasis.

Main Methods:

  • A systematic literature search of the PubMed Medline database was conducted in December 2013.
  • Keywords used included "psoriasis" and "photodynamic therapy".

Main Results:

  • Numerous clinical studies failed to demonstrate consistent efficacy for topical ALA-PDT in psoriasis.
  • Severe pain and burning sensations were frequently reported, often limiting patient tolerance.

Conclusions:

  • Topical ALA-PDT is unsuitable for chronic plaque psoriasis due to variable clinical response and adverse effects.
  • Alternative photosensitizers (hypericin, methylene blue, systemic ALA, verteporfin) show efficacy and better tolerability.
  • Visible spectrum light therapy presents a promising alternative to current PUVA and NB-UVB phototherapy for psoriasis.