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Related Concept Videos

Irritable Bowel Syndrome01:23

Irritable Bowel Syndrome

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DefinitionIrritable bowel syndrome (IBS) is a functional gastrointestinal disorder characterized by recurrent combinations of abdominal pain, bloating, diarrhea, or constipation.Pathophysiology of irritable bowel syndromeIts pathophysiology is multifactorial, involving disturbances in motility, sensory processing, microbial balance, barrier integrity, and gut–brain communication. These mechanisms interact to produce symptoms that vary across IBS subtypes.Altered Motility...
33
Irritable Bowel Syndrome I: Introduction01:17

Irritable Bowel Syndrome I: Introduction

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Irritable Bowel Syndrome (IBS) is characterized by functional disturbances in the gastrointestinal system, presenting a cluster of symptoms without evident structural or biochemical abnormalities. It primarily affects the large intestine and may cause abdominal pain, bloating, excessive gas, diarrhea, constipation, or both.
IBS is a chronic condition that can persist over a long period or recur frequently.
The pathogenesis of IBS involves a complex interplay of the following factors:
Altered...
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Chronic Bowel Disorders: Introduction01:17

Chronic Bowel Disorders: Introduction

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Chronic bowel diseases are a group of long-term conditions affecting the digestive tract, characterized by inflammation and damage to the gut lining. These conditions primarily include irritable bowel syndrome and inflammatory bowel disease.
Irritable Bowel Syndrome (IBS) is a common disorder affecting the gastrointestinal tract. The distinctive feature is recurrent abdominal pain associated with altered bowel movements, manifesting as constipation, diarrhea, or fluctuating between both. The...
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Irritable Bowel Syndrome III: Medical and Nursing Management01:30

Irritable Bowel Syndrome III: Medical and Nursing Management

987
Managing Irritable Bowel Syndrome (IBS) involves a multifaceted approach, including lifestyle modifications, dietary changes, and medication.
987
Drugs for Treatment of Diarrhea-Predominant IBS01:17

Drugs for Treatment of Diarrhea-Predominant IBS

1.0K
Diarrhea-predominant irritable bowel syndrome (IBS-D) is a subtype of IBS characterized primarily by frequent, loose, or watery stools, abdominal pain, and abdominal discomfort. Therapeutic approaches to managing IBS-D include dietary changes, stress management techniques, and pharmaceutical interventions.
Two specific drugs used in the treatment are alosetron (Lotronex) and eluxadoline (Viberzi). Alosetron, a 5-HT3 antagonist, works by slowing the movement of stools in the gut, reducing bowel...
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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation01:30

Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation

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Irritable Bowel Syndrome II: Clinical Features and Diagnostic Evaluation
Irritable Bowel Syndrome (IBS) is classified into subtypes based on the predominant bowel habits as determined by the Bristol Stool Form Scale (BSFS). The subtypes are:
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Does stress induce bowel dysfunction?

Yu-Ming Chang1, Mohamad El-Zaatari, John Y Kao

  • 1Department of Internal Medicine, Division of Gastroenterology, University of Michigan, 3912 Taubman Center, SPC 5362, 1500 East Medical Center Drive, Ann Arbor, MI, USA.

Expert Review of Gastroenterology & Hepatology
|June 3, 2014
PubMed
Summary
This summary is machine-generated.

Psychological stress can cause gut problems via the hypothalamus-pituitary-adrenal axis and other pathways. Emerging research suggests targeting gut microbiota may offer new treatments for stress-induced bowel dysfunction.

Keywords:
NLRP6bowel dysfunctionirritable bowel syndromemicrobiotastress

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Area of Science:

  • Neurogastroenterology
  • Microbiome research
  • Stress physiology

Background:

  • Psychological stress commonly triggers somatic symptoms, including gastrointestinal issues.
  • The hypothalamus-pituitary-adrenal (HPA) axis is a classical mediator of stress responses in the gut.
  • Growing evidence implicates corticotrophin-releasing factor (CRF) in stress-induced bowel dysfunction via multiple pathways.

Discussion:

  • CRF influences gut physiology through the HPA axis, autonomic nervous system, and direct effects on the bowel.
  • Stress-induced alterations in gut microbiota composition are increasingly recognized.
  • These findings highlight the complex interplay between stress, the gut, and the microbiome.

Key Insights:

  • CRF is a key mediator in stress-related bowel dysfunction.
  • Gut microbiota composition is affected by CRF.
  • Multiple pathways link stress to gut dysfunction.

Outlook:

  • Microbiota-modulating therapies, such as probiotics and antibiotics, show promise for treating stress-induced bowel dysfunction.
  • Further research into CRF's role and microbiota interactions could reveal novel therapeutic targets.
  • Understanding these mechanisms is crucial for developing effective interventions for functional gastrointestinal disorders.