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Updated: Apr 28, 2026
In Vivo Nanovector Delivery of a Heart-specific MicroRNA-sponge
Published on: June 15, 2018
miRNAs in PAH: biomarker, therapeutic target or both?
Jolyane Meloche1, Aude Pflieger1, Mylène Vaillancourt1
1Pulmonary Hypertension Group, Institut Universitaire de Cardiologie et de Pneumologie de Québec, Department of Medicine, Laval University, Quebec City G1V 4G5, Canada.
Abstract:
Pulmonary arterial hypertension (PAH) is characterized by progressive increase in pulmonary vascular resistance leading to right ventricular hypertrophy and failure. There is a need to find new biomarkers to detect PAH at its early stages and also for new, more effective treatments for this disease. miRNAs have emerged as key players in cardiovascular diseases and cancer development and progression and, more recently, in PAH pathogenesis. In this review, we focus on the potential of miRNAs as biomarkers and new therapeutic targets for PAH.
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