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Updated: Apr 28, 2026

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Lobular neoplasia.

Tari A King1, Jorge S Reis-Filho2

  • 1Breast Service, Department of Surgery, Memorial Sloan-Kettering Cancer Center, 300 East 66th Street, New York, NY, 10065, USA.

Surgical Oncology Clinics of North America
|June 3, 2014
PubMed
Summary

Lobular neoplasia (LN), a breast lesion linked to E-cadherin dysfunction, indicates risk for invasive breast cancer. Management remains controversial, with conservative approaches favored despite its precursor role.

Keywords:
Atypical lobular hyperplasiaBreast cancer riskChemopreventionE-cadherinLobular carcinoma in situLobular neoplasia

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Area of Science:

  • Oncology
  • Pathology
  • Genetics

Background:

  • Lobular neoplasia (LN) is defined by a faulty E-cadherin-catenin pathway, with E-cadherin loss driving typical LN cell morphology.
  • LN serves as a nonobligate precursor and risk indicator for invasive breast cancer, particularly invasive lobular carcinoma.

Purpose of the Study:

  • To provide an updated overview of the pathology and genetics of lobular neoplasia.
  • To discuss the current management strategies for LN in surgical practice.

Main Methods:

  • Review of current literature on lobular neoplasia pathology and genetics.
  • Analysis of clinical management controversies and current surgical practices.

Main Results:

  • E-cadherin dysfunction is a key feature of lobular neoplasia.
  • Lobular neoplasia is recognized as a precursor to invasive lobular carcinoma.
  • Clinical management decisions for LN are often debated, with conservative treatment being common.

Conclusions:

  • Understanding the pathology and genetics of LN is crucial for risk assessment.
  • Despite its precursor status, the clinical management of LN continues to be a subject of discussion.
  • Conservative management is the predominant approach for lobular neoplasia in surgical settings.