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Developing population pharmacokinetic parameters for high-dose methotrexate therapy: implication of correlations

Masahiro Watanabe1, Noriyasu Fukuoka, Toshiki Takeuchi

  • 1Department of Pharmacy, Kagawa University Hospital.

Biological & Pharmaceutical Bulletin
|June 3, 2014
PubMed
Summary

Bayesian estimation accurately predicts individual methotrexate (MTX) pharmacokinetic parameters using limited blood concentrations. Selecting population parameters with minimal correlation is crucial for precise MTX therapeutic drug monitoring.

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