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Significant decrease in plasma N-acetyl-seryl-aspartyl-lysyl-proline level in patients with end stage renal disease
Yosuke Suzuki1, Fumihiko Katagiri, Fuminori Sato
1Department of Clinical Pharmacy, Oita University Hospital.
Biological & Pharmaceutical Bulletin
|June 3, 2014
Summary
Plasma levels of N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP), an inhibitor of stem cell proliferation, decrease after kidney transplantation as renal function improves. This suggests AcSDKP levels are largely dependent on kidney function in end-stage renal disease patients.
Area of Science:
- Biochemistry
- Nephrology
- Immunology
Background:
- N-acetyl-seryl-aspartyl-lysyl-proline (AcSDKP) is an endogenous peptide that inhibits hematopoietic stem cell proliferation.
- AcSDKP is known to be involved in angiogenesis and renal fibroblast proliferation.
- Plasma AcSDKP levels may be affected by impaired renal function.
Purpose of the Study:
- To investigate the impact of improved renal function after kidney transplantation on plasma AcSDKP-like immunoreactive substance (IS) levels.
- To determine the relationship between renal function recovery and AcSDKP-IS levels post-transplantation.
Main Methods:
- Prospective study of 14 end-stage renal disease (ESRD) patients undergoing first kidney transplantation.
- Measurement of plasma AcSDKP-IS levels at multiple time points before and up to 90 days after transplantation.
- Assessment of creatinine clearance to evaluate renal function recovery.
Main Results:
- Plasma AcSDKP-IS levels significantly decreased from day 3 post-transplantation compared to pre-transplantation levels.
- Creatinine clearance significantly increased from day 7 post-transplantation.
- A significant negative correlation was found between creatinine clearance and plasma AcSDKP-IS levels, with creatinine clearance being the sole independent factor.
Conclusions:
- Recovery of kidney function following transplantation leads to a reduction in plasma AcSDKP levels in ESRD patients.
- Plasma AcSDKP levels appear to be significantly influenced by renal function in patients with ESRD.
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