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Related Concept Videos

MicroRNAs01:22

MicroRNAs

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns (non-coding regions of a gene) or intergenic regions (stretches of DNA present between genes). Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself, forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After the pre-miRNA...
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MicroRNAs01:22

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MicroRNA (miRNA) are short, regulatory RNA transcribed from introns—non-coding regions of a gene—or intergenic regions—stretches of DNA present between genes. Several processing steps are required to form biologically active, mature miRNA. The initial transcript, called primary miRNA (pri-mRNA), base-pairs with itself forming a stem-loop structure. Within the nucleus, an endonuclease enzyme, called Drosha, shortens the stem-loop structure into hairpin-shaped pre-miRNA. After...
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MicroRNAs01:22

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RNA Interference01:23

RNA Interference

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RNA interference (RNAi) is a process in which a small non-coding RNA molecule blocks the post-transcriptional expression of a gene by binding to its messenger RNA (mRNA) and preventing the protein from being translated.
This process occurs naturally in cells, often through the activity of genomically-encoded microRNAs. Researchers can take advantage of this mechanism by introducing synthetic RNAs to deactivate specific genes for research or therapeutic purposes. For example, RNAi could be used...
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Experimental RNAi02:15

Experimental RNAi

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RNA interference (RNAi) is a cellular mechanism that inhibits gene expression by suppressing its transcription or activating the RNA degradation process. The mechanism was discovered by Andrew Fire and Craig Mello in 1998 in plants. Today, it is observed in almost all eukaryotes, including protozoa, flies, nematodes, insects, parasites, and mammals. This precise cellular mechanism of gene silencing has been developed into a technique that provides an efficient way to identify and determine the...
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Related Experiment Video

Updated: Apr 28, 2026

MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method
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MicroRNA Amplification and Recognition through Locked-nucleic-acid In situ Hybridization as a Novel Detection and Quantification Method

Published on: October 7, 2025

554

MicroRNA and implantation.

Daniela Galliano1, Antonio Pellicer2

  • 1Division of Reproductive Medicine, Instituto Valenciano de Infertilidad, Barcelona, Spain.

Fertility and Sterility
|June 3, 2014
PubMed
Summary

MicroRNAs show promise as diagnostic markers for human implantation disorders, including infertility and ectopic pregnancy. Further research is needed for their clinical application in diagnosing and treating implantation failure.

Keywords:
BlastocystPULectopic pregnancyendometrial receptivityimplantationmiRNAs

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Area of Science:

  • Reproductive biology
  • Molecular diagnostics
  • Genetics

Background:

  • MicroRNAs (miRNAs) are small non-coding RNAs involved in gene regulation.
  • Implantation is a complex process crucial for successful pregnancy.
  • Dysregulation of miRNAs is implicated in various reproductive disorders.

Purpose of the Study:

  • To review the role of microRNAs in human implantation.
  • To explore the diagnostic potential of miRNAs in implantation-related conditions.
  • To assess miRNAs as therapeutic targets for implantation failure.

Main Methods:

  • Literature review of studies on microRNAs and human implantation.
  • Analysis of miRNA expression patterns in different implantation scenarios.
  • Evaluation of current evidence for diagnostic and therapeutic applications.

Main Results:

  • MicroRNAs are implicated in endometrial receptivity and embryo development.
  • miRNAs show potential as biomarkers for assisted reproduction technology (ART) failure, ectopic pregnancy, and pregnancies of unknown location.
  • Altered miRNA profiles are associated with implantation disorders.

Conclusions:

  • MicroRNAs represent emerging diagnostic markers for implantation disorders.
  • miRNAs may serve as future therapeutic tools for reproductive medicine.
  • Clinical application requires further investigation and validation.