Search research articles

ABOUT JoVE

Overview Leadership Blog JoVE Help Center

AUTHORS

Publishing Process Editorial Board Scope & Policies Peer Review FAQ Submit

LIBRARIANS

Testimonials Subscriptions Access Resources Library Advisory Board FAQ

RESEARCH

JoVE Journal Methods Collections JoVE Encyclopedia of Experiments Archive

EDUCATION

JoVE Core JoVE Business JoVE Science Education JoVE Lab Manual Faculty Resource Center Faculty Site

Terms & Conditions of Use

Related Concept Videos

Treatment Resistant Cancers

Treatment Resistant Cancers

Cancer is the second leading cause of death in the United States. A cancer cell is genetically unstable and hence can mutate faster. They can also modify their microenvironment and escape immune surveillance. The difficulties in treating cancer are further compounded by the emergence of rapid resistance to anticancer drugs. The most common ways to attain resistance in cancer cells include alteration in drug transport and metabolism, modification of drug target, elevated DNA damage response, or...

Tumor Immunotherapy

Tumor Immunotherapy

Immunotherapy is a treatment that boosts or manipulates the immune system to fight diseases, including cancer. For instance, by stimulating an immune response through vaccinations against viruses that cause cancers, like hepatitis B virus and human papillomavirus, these diseases can be prevented. Nonetheless, some cancer cells can avoid the immune system due to their rapid mutation and division. The immune response to many cancers involves three phases: elimination, equilibrium, and escape.

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose Veins II: Diagnostic Studies and Interprofessional Care

Varicose veins, or varicosities, develop when the valves in the veins, which control blood flow, weaken or damage. It causes blood to pool and the veins to enlarge. Understanding the clinical manifestations, diagnostic approaches, and management options for varicose veins is crucial for effective treatment and relief.Clinical manifestationsClinical manifestations of varicose veins include a heavy, achy feeling or pain after prolonged standing or sitting. This discomfort can often be relieved by...

Cancer Therapies

Cancer Therapies

Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by

Same author

Transvaginal sonography-guided aspiration of benign ovarian cysts: a retrospective evaluation of safety, feasibility, and economic and environmental implications.

Archives of gynecology and obstetrics·2026

Same author

Impact of diagnostic laparoscopy on resectability and treatment strategy in FIGO III-IV ovarian cancer.

Archives of gynecology and obstetrics·2025

Same author

Preoperative colonoscopy in ovarian cancer: impact on surgical planning and outcomes: results from a retrospective, single-center study.

Archives of gynecology and obstetrics·2025

Same author

Epidemiological impact of a large number of false negative SARS-CoV-2 test results in South West England during September and October 2021.

Epidemics·2024

Same author

Diagnostics and Therapy of Venous Thrombosis and Pulmonary Embolism. The revised AWMF S2k Guideline

VASA. Zeitschrift fur Gefasskrankheiten·2023

Same author

Correction to: Teaching undergraduate students gynecological and obstetrical examination skills: the patient's opinion.

Archives of gynecology and obstetrics·2021

Search research articles

Related Experiment Video

Updated: Apr 28, 2026

Author Spotlight: Dermatopathology and the Treatment of Sexually Transmitted Diseases

Author Spotlight: Dermatopathology and the Treatment of Sexually Transmitted Diseases

Published on: November 8, 2024

Therapy for Primary Vulvar Carcinoma.

D Herr¹, I Juhasz-Boess¹, E F Solomayer¹

¹Frauenklinik, Universitätsklinikum Homburg/Saar, Homburg, Saar.

Geburtshilfe Und Frauenheilkunde

|June 3, 2014

Summary

Vulvar cancer, typically squamous cell carcinoma, often arises from HPV infection or VIN. Treatment focuses on surgical resection and adjuvant radiotherapy for positive lymph nodes, with limited roles for systemic therapies.

Keywords:

cancer therapy vulva

More Related Videos

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

Vessel-sparing Excision and Primary Anastomosis

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

Related Experiment Videos

Last Updated: Apr 28, 2026

Author Spotlight: Dermatopathology and the Treatment of Sexually Transmitted Diseases

Author Spotlight: Dermatopathology and the Treatment of Sexually Transmitted Diseases

Published on: November 8, 2024

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

An Orthotopic Endometrial Cancer Model with Retroperitoneal Lymphadenopathy Made From In Vivo Propagated and Cultured VX2 Cells

Published on: September 12, 2019

Vessel-sparing Excision and Primary Anastomosis

Vessel-sparing Excision and Primary Anastomosis

Published on: January 7, 2019

Area of Science:

Oncology
Gynecologic Oncology

Background:

Vulvar cancer is a rare malignancy, predominantly squamous cell carcinoma.
Pathogenesis may involve human papillomavirus (HPV) infection, vulvar intraepithelial neoplasia (VIN), lichen sclerosus et atrophicans, immune deficiency, nicotine abuse, or anogenital intraepithelial neoplasias.

Purpose of the Study:

To outline the current therapeutic strategies for vulvar cancer.
To emphasize the importance of surgical management and adjuvant radiotherapy in specific cases.

Main Methods:

Surgical resection techniques including radical vulvectomy, local excision with reconstruction, and vulvar field resection.
Inguinofemoral lymphadenectomy and sentinel lymph node biopsies for staging.
Evaluation of systemic therapies (neoadjuvant chemotherapy, adjuvant chemotherapy) and radiotherapy (neoadjuvant, adjuvant).

Main Results:

Surgical goal is R0 resection (complete removal).
Sentinel biopsies are utilized in select cases by experienced surgeons.
Systemic therapy has a limited role; neoadjuvant chemotherapy may aid down-staging, but adjuvant chemotherapy is not indicated.
Adjuvant radiotherapy is indicated for positive inguinal lymph nodes and should be considered broadly in such instances.

Conclusions:

Current treatment emphasizes surgical expertise and judicious use of adjuvant radiotherapy.
Systemic therapies are generally reserved for specific situations, with limited evidence supporting their routine use.