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A clinicopathologic study of thirty cases of acquired perforating dermatosis in Korea
Seo Wan Kim1, Mi Sun Kim1, June Hyunkyung Lee1
1Department of Dermatology, Eulji General Hospital, Eulji University, Seoul, Korea.
Background:
Acquired perforating dermatosis (APD) is histopathologically characterized by transepidermal elimination of materials from the upper dermis. APD can be divided into four diseases: Kyrle's disease, perforating folliculitis, elastosis perforans serpiginosa, and reactive perforating collagenosis. APD is usually associated with systemic diseases, especially diabetes mellitus or chronic renal failure. So far, there have only been a few Korean studies of APD, which have a limited number of patients.
Objective:
The aim of this study is to evaluate the clinical and histopathologic characteristics of 30 cases of APD and to examine the association with systemic diseases.
Methods:
We retrospectively reviewed the medical records and biopsy specimens of 30 patients who were diagnosed with APD.
Results:
The mean age was 55.5 years, and the average duration of the lesion was 7.8 months. The lower extremities (73.3%) were the most frequently occurring sites of the lesion. Twenty-five patients (83.3%) had pruritus, and Koebner's phenomenon was present in 11 patients. Patients of 63.3% had at least one systemic disease. Diabetes mellitus (n=17, 56.7%) and chronic renal failure (n=10, 33.3%) were the most commonly associated conditions. Most patients received topical steroids (93.3%) and antihistamines (80.0%). The most common histopathologic type was reactive perforating collagenosis (n=23, 73.3%).
Conclusion:
In this study, most patients had a systemic association to the diseases. Therefore, we suggest that further evaluation is necessary for patients who present with APD. This includes reviewing patient's comprehensive past medical history, clinical exam, and additional diagnostic testing to check for the possibility of associated systemic diseases.
Insights
Acquired perforating dermatosis (APD) often links to systemic diseases like diabetes. Further patient evaluation is recommended for associated conditions.
Area of Science:
- Dermatology
- Pathology
Background:
- Acquired perforating dermatosis (APD) is characterized by transepidermal elimination of dermal materials.
- It encompasses Kyrle's disease, perforating folliculitis, elastosis perforans serpiginosa, and reactive perforating collagenosis.
- APD frequently co-occurs with systemic conditions, notably diabetes mellitus and chronic renal failure.
Purpose of the Study:
- To analyze the clinical and histopathologic features of 30 APD cases.
- To investigate the association between APD and systemic diseases.
Main Methods:
- Retrospective review of medical records and biopsy specimens from 30 diagnosed APD patients.
Main Results:
- The average patient age was 55.5 years, with lesions lasting 7.8 months.
- Lower extremities were the most affected sites (73.3%).
- A significant majority (83.3%) experienced pruritus, and 63.3% had at least one systemic disease, primarily diabetes mellitus (56.7%) and chronic renal failure (33.3%). Reactive perforating collagenosis was the most common histopathologic type (73.3%).
Conclusions:
- Most APD cases are linked to systemic diseases.
- Comprehensive patient evaluation, including medical history, clinical examination, and diagnostic testing, is crucial for identifying associated systemic conditions.
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