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Updated: Apr 28, 2026

Profiling Sensitivity to Targeted Therapies in EGFR-Mutant NSCLC Patient-Derived Organoids
Published on: November 22, 2021
Meeting the current and future challenges of oncology drug development
Moira Howie1, Kathy Oliver2, Angela Timoney3
1Eli Lilly and Company, Lilly UK, Surrey, UK.
Abstract:
This breakout session highlighted four distinct perspectives from leading individuals within patient advocacy, industry, an appraisal committee and physicians on the future and challenges faced by targeted therapy in HTA evaluation. Bringing together leaders from key stakeholders in the process, it gave participants the opportunity to examine how the same HTA evaluation process is interpreted from multiple perspectives. The presentation of an industry supported "Six Nation Public Opinion Survey of Cancer Knowledge and Attitudes" provided detailed insight into how the general public, patients and caregivers view cancer alongside various available and possible future therapies. An interactive 'perspectives activity' session provided all participants with an opportunity to think through and discuss the HTA process, and its challenges, from the four distinct positions involved. We declare that we have no conflicts of interest.
Insights
Understanding patient perspectives on targeted therapy is crucial for health technology assessment (HTA). This session explored challenges and diverse viewpoints on HTA evaluations for cancer treatments.
Area of Science:
- Oncology
- Health Economics
- Health Policy
Background:
- Targeted therapy represents a significant advancement in cancer treatment.
- Health Technology Assessment (HTA) is critical for evaluating new therapies.
- Diverse stakeholder perspectives influence HTA outcomes.
Purpose of the Study:
- To explore the future and challenges of targeted therapy within HTA.
- To examine the HTA evaluation process from multiple stakeholder viewpoints.
- To understand public, patient, and caregiver attitudes towards cancer therapies.
Main Methods:
- A breakout session featuring leaders from patient advocacy, industry, appraisal committees, and physicians.
- Presentation of a "Six Nation Public Opinion Survey of Cancer Knowledge and Attitudes".
- An interactive 'perspectives activity' simulating the HTA process from different roles.
Main Results:
- Highlighted distinct interpretations of the HTA process by key stakeholders.
- Provided insights into public and patient perceptions of cancer and its therapies.
- Facilitated discussion on the complexities and challenges within HTA.
Conclusions:
- Emphasized the importance of considering multiple perspectives in HTA for targeted therapies.
- Underscored the need for better understanding of patient and public views in cancer treatment evaluation.
- Identified key challenges in the HTA process that require collaborative solutions.
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