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PET/CT in Oncology: Current Status and Perspectives
Johannes Czernin1, Martin Allen-Auerbach1, David Nathanson1
1Ahmanson Translational Imaging Division, Department of Molecular and Medical Pharmacology, David Geffen School of Medicine, University of California, Los Angeles, 10833 Le Conte Avenue, Room AR-23-222 CHS, Los Angeles, CA 90095-1782 USA.
Positron emission tomography/computed tomography (PET/CT) has revolutionized patient care. This review explores PET/CT
Area of Science:
- Oncology
- Nuclear Medicine
- Radiology
Background:
- The Warburg effect discovery and 18F-fluorodeoxyglucose (18F-FDG) development underpin clinical PET/CT.
- Early positron emission tomography (PET) laid the groundwork for modern imaging.
Purpose of the Study:
- To review challenges and advances in clinical PET/CT adoption.
- To highlight the clinical utility, cost-effectiveness, and impact of PET/CT on patient outcomes.
- To discuss various PET molecular imaging approaches for cancer phenotyping.
Main Methods:
- Review of instrumentation advancements, focusing on PET/CT.
- Analysis of current PET/CT protocols and clinical utility evidence.
- Exploration of 18F-FDG imaging and alternative PET molecular imaging techniques.
Main Results:
- PET/CT has overcome adoption challenges through instrumentation and protocol advancements.
- PET/CT demonstrates significant clinical utility in patient management and outcomes.
- Computed tomography (CT) integration critically enhances PET/CT's diagnostic strength.
Conclusions:
- PET/CT is a vital tool in oncology, offering valuable insights into cancer phenotyping.
- Continued advancements in PET/CT technology and protocols are crucial for its widespread adoption and effectiveness.
- The synergistic combination of PET and CT provides a powerful platform for personalized cancer management.
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