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OLIgo Mass Profiling OLIMP of Extracellular Polysaccharides

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Published on: June 20, 2010

Bioactive oligosaccharide natural products.

Emilianne K McCranie¹, Brian O Bachmann

¹Department of Chemistry, Vanderbilt University, Nashville, Tennessee 37240, USA. brian.bachmann@vanderbilt.edu.

Natural Product Reports

|June 3, 2014

Summary

Bioactive oligosaccharides show promise for treating bacterial infections and type II diabetes. This review explores their unique actions and biosynthesis, focusing on four key classes.

Area of Science:

Natural product chemistry
Carbohydrate chemistry
Microbiology
Biochemistry

Background:

Oligosaccharides are natural products with diverse biological activities.
They can disrupt bacterial cell wall biosynthesis and inhibit human enzymes like alpha-amylase.
Potential applications include treatments for bacterial infections and type II diabetes.

Purpose of the Study:

To review the modes of action of bioactive oligosaccharides.
To highlight the biosynthesis of these compounds.
To focus on four specific classes: orthosomycins, moenomycins, saccharomicins, and acarviostatins.

Main Methods:

Literature review of scientific publications up to December 2013.
Analysis of reported biological activities and biosynthetic pathways.

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Categorization of oligosaccharides based on their structure and function.

Main Results:

Oligosaccharides exhibit potent and selective biological activities.
Their biosynthesis pathways are less understood compared to other natural products.
Four classes (orthosomycins, moenomycins, saccharomicins, acarviostatins) have distinct mechanisms and biosynthetic routes.

Conclusions:

Bioactive oligosaccharides represent a promising area for drug discovery.
Further research into their biosynthesis is crucial for unlocking their full therapeutic potential.
Understanding these compounds can lead to novel treatments for various diseases.