Related Experiment Video
Updated: Apr 28, 2026
06:44
A Mouse Model for Chronic Pancreatitis via Bile Duct TNBS Infusion
Published on: February 28, 2021
3.6K
Autoimmune pancreatitis can develop into chronic pancreatitis.
Masahiro Maruyama, Takayuki Watanabe, Keita Kanai
1Center for Health, Safety, and Environmental Management, Shinshu University, 3-1-1 Asahi, Matsumoto 390-8621, Japan. skawapc@shinshu-u.ac.jp.
Orphanet Journal of Rare Diseases
|June 3, 2014
Summary
Autoimmune pancreatitis (AIP) can progress to chronic pancreatitis, often presenting with pancreatic stones. Early detection and management are key to improving long-term outcomes for AIP patients.
Area of Science:
- Gastroenterology
- Immunology
- Pathology
Background:
- Autoimmune pancreatitis (AIP) is a distinct pancreatitis subtype linked to autoimmune mechanisms.
- AIP is identified by elevated serum IgG4 and IgG4-positive plasma cell infiltration.
- Corticosteroid therapy effectively treats acute AIP, but long-term outcomes are not well-defined.
Purpose of the Study:
- To investigate the long-term prognosis of autoimmune pancreatitis.
- To test the hypothesis that AIP can evolve into chronic pancreatitis.
- To identify risk factors for disease progression and complications.
Main Methods:
- Review of clinical findings and study results related to AIP.
- Analysis of pancreatic stone formation in AIP patients.
- Evaluation of progression to chronic pancreatitis based on diagnostic criteria.
Main Results:
- Pancreatic calcification in AIP correlates with disease recurrence.
- Approximately 40% of AIP patients develop pancreatic stones long-term, linked to duct narrowing.
- Nearly 20% of AIP patients progress to chronic pancreatitis, with risk factors including pancreatic head swelling and duct characteristics.
Conclusions:
- Autoimmune pancreatitis may progress to chronic pancreatitis over time.
- Pancreatic stone formation is a significant long-term complication associated with AIP recurrence and ductal changes.
- Identifying risk factors like pancreatic head swelling and duct narrowing is crucial for predicting AIP progression.
Related Concept Videos
01:25Chronic Pancreatitis I: Introduction
25
Chronic pancreatitis is a long-standing, relapsing inflammation of the pancreas, characterized by irreversible damage to the gland. It results in progressive destruction of the pancreatic parenchyma, fibrosis, and eventual loss of both exocrine and endocrine function. The disease may evolve gradually after multiple episodes of acute pancreatitis or develop independently.EtiologyChronic pancreatitis can arise from a variety of causes:Alcohol use is the leading cause, accounting for 70–80%...
25
01:24Chronic Pancreatitis I: Introduction
903
The pancreas, an elongated and flat gland situated behind the stomach, serves a vital function in digesting food and managing blood sugar levels.
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
Pancreatitis is the inflammation of the pancreas, which occurs when the immune system becomes active and causes swelling, pain, and disruptions in organ function. Pancreatitis can manifest as either an acute or chronic condition.
Acute pancreatitis arises suddenly and lasts for a brief duration, while chronic pancreatitis is a long-term affliction...
903
01:21Chronic Pancreatitis II: Pathophysiology
26
Chronic pancreatitis is a progressive and irreversible inflammation of the pancreas, most often caused by long-term alcohol abuse, but it can also be related to ductal obstruction, smoking, or genetic factors.Chronic pancreatitis occurs when the pancreas is repeatedly exposed to harmful agents like alcohol, smoking, ductal obstruction, or genetic predisposition. These factors lead to the release of toxic metabolites and inflammatory cytokines, sustaining chronic inflammation in the pancreatic...
26
01:21Acute Pancreatitis II: Pathophysiology
40
The pathophysiology of acute pancreatitis centers on injury to pancreatic acinar cells, which initiates a cascade of harmful intracellular events.This injury leads to premature activation of trypsinogen to trypsin in the pancreas. Trypsin then activates other digestive enzymes, such as chymotrypsin, elastase, and phospholipase A2, which begin breaking down pancreatic tissue. The resulting autodigestion causes local inflammation, tissue swelling, hemorrhage, and fat necrosis.Injured acinar cells...
40
01:27Acute Pancreatitis I: Introduction
1.5K
Pancreatitis is inflammation of the pancreas, an organ located behind the stomach. It can be either acute or chronic.
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
Acute pancreatitis is characterized by rapid inflammation of the pancreas, often caused by factors like gallstone blockage or excessive alcohol consumption. Chronic pancreatitis, on the other hand, is a slow, progressive inflammation that may result from long-term alcohol abuse, obstructions in the pancreatic duct, or genetic factors.
The causes of acute pancreatitis include:
1.5K
01:25Acute Pancreatitis I: Introduction
19
Acute pancreatitis is the sudden inflammation of the pancreas caused by the early activation of digestive enzymes, leading to the autodigestion of pancreatic tissue. This results in local inflammation and, in severe cases, systemic complications.EtiologyUnderstanding the underlying causes is crucial, as identifying the etiology guides treatment and anticipates complications. Acute pancreatitis can be triggered by various factors, typically grouped into the following clinical categories.Biliary...
19