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[Leukocytoclastic vasculitis and malignant hematologic diseases. (12 cases)]
J Beylot1, M Malou, M S Doutre
1Service de médecine interne, Hôpital Saint-André, Bordeaux.
La Revue De Medecine Interne
|November 1, 1989
Summary
Leukocytoclastic vasculitis can indicate underlying myelocytic or lymphocytic blood diseases. Early investigation for blood disorders is crucial in patients presenting with vasculitis.
Area of Science:
- Hematology
- Dermatology
- Pathology
Background:
- Leukocytoclastic vasculitis (LCV) is an inflammatory condition affecting small blood vessels.
- The association between LCV and hematologic malignancies is recognized but requires further elucidation.
Observation:
- This study details 12 cases of LCV linked to myelocytic (7 cases) or lymphocytic (5 cases) blood diseases.
- Exclusion criteria included drug-induced/infective origins and cryoglobulinemia.
- The temporal relationship between LCV and blood disease varied: preceding, simultaneous, or concurrent development, with no apparent impact on prognosis.
Findings:
- Pathological findings and clinical features of these associated cases are presented.
- The pathogenesis is multifactorial, likely involving tumoral immune complexes and deficiencies in phagocytic cells or chemotactic factors.
Implications:
- LCV can be an early indicator of underlying myelocytic or lymphocytic blood diseases.
- Investigating for hematologic malignancies in patients with cutaneous or systemic vasculitis is recommended, similar to the approach for pyoderma gangrenosum or Sweet's syndrome.