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suPAR and Team Nephrology
1NYU Langone Medical Center, Department of Pediatrics, Division of Nephrology, CTSI, 227 E 30th Street, Room #110, New York, NY, USA. howard.trachtman@nyumc.org.
BMC Medicine
|June 3, 2014
Summary
Urinary soluble urokinase receptor (suPAR) helps differentiate primary focal segmental glomerulosclerosis (FSGS) from other kidney diseases. High plasma suPAR levels do not correlate with reduced glomerular filtration rate (GFR), suggesting further research is needed.
Area of Science:
- Nephrology
- Biomarker Discovery
Background:
- Primary focal segmental glomerulosclerosis (FSGS) is a leading cause of kidney failure.
- Soluble urokinase receptor (suPAR) has been proposed as a biomarker for FSGS, but its diagnostic utility is debated.
Purpose of the Study:
- To evaluate the role of urinary and plasma suPAR in distinguishing primary FSGS from other glomerular diseases.
- To assess the relationship between plasma suPAR levels and glomerular filtration rate (GFR) in FSGS patients.
Main Methods:
- Analysis of urinary and plasma suPAR levels in patients with FSGS and other glomerular diseases.
- Correlation analysis between plasma suPAR concentrations and GFR.
Main Results:
- Urinary suPAR excretion effectively distinguishes primary FSGS from other glomerular diseases.
- Elevated plasma suPAR concentrations were not directly associated with a decline in GFR.
Conclusions:
- Urinary suPAR shows promise as a diagnostic biomarker for primary FSGS.
- Plasma suPAR levels may not be a direct indicator of kidney function decline in FSGS.
- Further investigation of suPAR and other novel biomarkers like B7-1 is crucial for advancing FSGS treatment.
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