Nail disorders in infants and children
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Updated: Apr 28, 2026

Assessment and Evaluation of the High Risk Neonate: The NICU Network Neurobehavioral Scale
Published on: August 25, 2014
Bianca Maria Piraccini1, Michela Starace
1Division of Dermatology, Department of Experimental, Diagnostic and Specialty Medicine, University of Bologna, Bologna, Italy.
Insights
Pediatric nail diseases, though uncommon, require expert diagnosis. This review aids in early recognition and management of common congenital, hereditary, inflammatory, infective, and neoplastic nail conditions in children.
Area of Science:
- Pediatric Dermatology
- Nail Biology
- Clinical Diagnostics
Background:
- Nail diseases in infants and children are infrequently encountered and pose diagnostic challenges.
- Accurate diagnosis and management are crucial for pediatric patients.
Purpose of the Study:
- To provide a comprehensive overview of common pediatric nail diseases.
- To assist healthcare professionals in early recognition and appropriate management of nail disorders in young patients.
Main Methods:
- Literature review focusing on congenital, hereditary, inflammatory, infective, and neoplastic nail diseases.
- Synthesis of findings from recent large studies on genetic nail disorders like pachyonychia congenita and epidermolysis bullosa.
Main Results:
- Recent research highlights clinical findings in genetic nail disorders, including pachyonychia congenita and epidermolysis bullosa.
- The majority of recent literature focuses on individual case reports, with few comprehensive disease reviews.
Conclusions:
- Diagnosing pediatric nail conditions can be difficult for non-specialists.
- Understanding nail anatomy, biology, and pathophysiology is key to accurate diagnosis.
- This review offers guidance on common nail diseases affecting infants and children.
Purpose Of Review:
Nail diseases in infants and children are an uncommon cause of consultation and are often difficult to diagnose and to manage. This review will cover nail diseases that are most commonly seen in clinical practice, including congenital and hereditary disorders and inflammatory, infective, and neoplastic nail diseases. The purpose of the review is to help the reader to recognize nail disorders at an early age and to manage them appropriately.
Recent Findings:
Two recent large studies have reported the clinical findings of genetic disorders involving the nails, that is, pachyonychia congenita and epidermolysis bullosa. Only a few articles gave a comprehensive review of a disease, as occurred for onychomycosis, while the majority of the reports published in the recent literature involve single cases.
Summary:
Nail diseases in children and neonates are not easy to diagnose by nonexperts. Basic knowledge of the anatomy and biology of the nail facilitates their diagnosis as the understanding of their pathophysiology. This review gives hints at the most common nail diseases that affect infants and children.
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