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Related Concept Videos

Asthma I: Introduction01:28

Asthma I: Introduction

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Asthma is a chronic inflammatory disorder of the airways characterized by variable airflow obstruction and heightened bronchial responsiveness to a wide range of triggers. The underlying inflammation leads to airway swelling, mucus hypersecretion, and smooth muscle constriction, all of which narrow the airway lumen and impede airflow. Clinically, asthma presents with recurrent episodes of wheezing, shortness of breath, chest tightness, and coughing, symptoms that typically vary in intensity and...
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Asthma III: Clinical Manifestations01:13

Asthma III: Clinical Manifestations

39
Asthma presents with a characteristic pattern of episodic respiratory symptoms that reflect underlying airway inflammation, bronchoconstriction, and mucus hypersecretion. Although severity varies among individuals, certain clinical manifestations are considered hallmarks of the disorder and often guide diagnosis and assessment.Respiratory SymptomsA persistent cough is one of the most common early features of asthma. It is frequently dry and tends to worsen at night or in the early morning,...
39
Asthma: Pathogenesis and Management01:20

Asthma: Pathogenesis and Management

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Asthma is a chronic pulmonary condition involving inflammation of the airways, hyper-reactivity, and reversible obstruction of the airways. This condition can significantly impact a person's quality of life, making breathing difficult and leading to distressing symptoms.
Asthma is classified as allergic and non-allergic. Allergens such as dust mites, pollen, and pet dander trigger allergic asthma, while factors like cold air, intense emotions, or exercise can induce non-allergic asthma.
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Asthma-II: Pathophysiology and Classification01:26

Asthma-II: Pathophysiology and Classification

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Asthma is a prevalent chronic respiratory condition marked by inflammation and hyperresponsiveness of the airways. Its pathophysiology involves complex interactions among inflammatory pathways, immune responses, and neural mechanisms.
Additionally, environmental and genetic factors play crucial roles in determining an individual's susceptibility to asthma and the severity of their condition.
Critical processes in asthma pathophysiology include:
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Asthma-I: Introduction01:29

Asthma-I: Introduction

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Asthma is a chronic respiratory ailment that requires careful management due to its varying symptoms and influencing factors. It is characterized by airway inflammation, bronchial hyperresponsiveness, and reversible airflow obstruction, leading to symptoms like wheezing, shortness of breath, chest tightness, and coughing. The symptom frequency and intensity may vary considerably over time. It is also linked to immune system responses to allergens and irritants, highlighting the complex...
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Asthma-III: Symptoms and Complications01:24

Asthma-III: Symptoms and Complications

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Asthma, a common chronic respiratory condition, is classified considering the frequency and severity of symptoms alongside lung function impairment. Understanding this classification is essential for appropriate treatment and management. Here's a detailed look at the classification of asthma and its clinical features and complications:
Classification of Asthma
3.5K

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Related Experiment Video

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Resolving Water, Proteins, and Lipids from In Vivo Confocal Raman Spectra of Stratum Corneum through a Chemometric Approach
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New insights into the allergic march.

Marcus Shaker1

  • 1Department of Pediatrics, Section of Allergy, Asthma, and Immunology, Children's Hospital at Dartmouth, Lebanon New Hampshire, USA.

Current Opinion in Pediatrics
|June 3, 2014
PubMed
Summary

The allergic march links atopic dermatitis, food allergy, asthma, and rhinitis. Understanding these connections, including genetic factors like filaggrin mutations, aids early diagnosis and prevention.

Area of Science:

  • Pediatric Allergy and Immunology
  • Dermatology
  • Genetics

Background:

  • The allergic march describes the progression of allergic diseases in children, starting with atopic dermatitis.
  • Increasing prevalence of allergic diseases, particularly food allergies, presents a significant public health challenge.

Purpose of the Study:

  • To review current understanding of the allergic march of childhood.
  • To explore new insights into the associations between atopic dermatitis, food allergy, asthma, and allergic rhinitis.
  • To highlight recent advancements in understanding genetic risk factors and management strategies.

Main Methods:

  • Literature review of recent research on the allergic march.
  • Analysis of genetic factors, including filaggrin mutations.

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  • Examination of new paradigms in disease interrelationships and treatment approaches.

    • Main Results:

    • Filaggrin mutations represent a significant genetic risk factor for the allergic march.
    • New understandings of the interplay between atopic dermatitis, food allergy, and asthma are emerging.
    • Research is advancing in food allergy prevention and treatment, and in predicting asthma treatment response.

    Conclusions:

    • Understanding the interconnectedness of atopic diseases facilitates earlier diagnosis in at-risk children.
    • This knowledge may lead to innovative strategies for health promotion and disease prevention.
    • Updated guidelines on allergen avoidance inform management of allergic phenotypes.