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Updated: Apr 28, 2026

Developing a Rat Model for Bipolar Disorder
Published on: May 2, 2025
[Bipolar disorder and DSM-5: still far from the disease]
Diego J Martino1, Sergio A Strejilevich
1Programa de Investigación en Trastornos Bipolares, Instituto de Neurociencias, Universidad Favaloro, Buenos Aires, Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Argentina. diejmartino@gmail.com.
Abstract:
Although bipolar disorder is highly disabling, data from different regions of the world agree on the finding that there is a prolonged diagnostic delay in affected people. Among the main factors that could explain this phenomenon are contemporary conceptualizations of bipolar disorder and diagnostic criteria of the DSM-IV. Moreover, in recent years it has been cautioned about the risk of overdiagnosis of this disorder. In this context, the new edition of the DSM is presented. The modifications included in the DSM-5 regarding the diagnosis of bipolar disorder are described in this paper. Likewise, the practical implications of these changes are discussed.
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