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An easy route to synthetic analogues of radicamine B, codonopsine and codonopsinine from D-mannitol
Suresh Dharuman1, Ashok Kumar Palanivel, Yashwant D Vankar
1Department of Chemistry, Indian Institute of Technology, Kanpur 208 016, India. vankar@iitk.ac.in.
Organic & Biomolecular Chemistry
|June 3, 2014
Abstract:
A general strategy for the synthesis of analogues of radicamine B has been carried out from D-mannitol. This method has been further extended to the synthesis of analogues of codonopsine and codonopsinine using appropriate Grignard reagents. The hence obtained molecules have been tested against various commercially available glycosidases and found to act as moderate to good inhibitors.