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[Thyroid function tests in a sample of hospitalized patients].

J Halabe-Cherem1, H Nellen-Hummel, F Gordon-Barabezki

  • 1Departamento de Medicina Interna, Hospital de Especialidades, CMN (IMSS), México, D. F.

Archivos De Investigacion Medica
|October 1, 1989
PubMed
Summary

Hospitalized patients often exhibit altered thyroid function tests, including triiodothyronine (T3) and thyroxine (T4) levels. Severity of illness correlates with thyroid function abnormalities, impacting diagnosis and patient outcomes.

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Area of Science:

  • Endocrinology
  • Internal Medicine
  • Critical Care Medicine

Background:

  • Thyroid hormones (T3, T4) and thyroid-stimulating hormone (TSH) are crucial for metabolic regulation.
  • Hospitalized patients, particularly those in intensive care, may experience significant physiological stress affecting thyroid function.
  • Non-thyroidal illness syndrome (NTIS) is a common phenomenon in critically ill patients, characterized by altered thyroid hormone levels.

Purpose of the Study:

  • To investigate serum thyroid hormone levels (T3, T4, TSH) in hospitalized patients.
  • To compare thyroid function in patients admitted to Internal Medicine versus Intensive Care Units (ICUs).
  • To assess the correlation between thyroid function test abnormalities and disease severity.

Main Methods:

  • Serum T3, T4, and TSH levels were measured in 26 Internal Medicine patients, 27 ICU patients, and 25 healthy volunteers.

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  • Patients were categorized into groups based on their ward of admission (Internal Medicine vs. ICU).
  • Thyroid function test results were analyzed and compared across the groups, with a focus on identifying abnormal levels and their prevalence.

    • Main Results:

    • Mean T3 and T4 levels tended to be lower in hospitalized patients compared to healthy controls, with a more pronounced trend in severe cases, though not statistically significant.
    • Abnormal thyroid function tests were observed in 52.8% of hospitalized patients.
    • The ratio of normal to abnormal thyroid function tests differed significantly between sick and healthy individuals, and between ICU and Internal Medicine patients, suggesting a correlation with illness severity.

    Conclusions:

    • Hospitalized patients frequently present with alterations in thyroid function tests.
    • The degree of thyroid function abnormality appears to correlate with the severity of illness, distinguishing between Internal Medicine and ICU populations.
    • These findings highlight the importance of monitoring thyroid function in hospitalized patients, especially in critical care settings.