Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Mesenchymal Stem Cells01:19

Mesenchymal Stem Cells

4.5K
Mesenchymal stem cells (MSCs) are adult stem cells that can differentiate into most connective tissue cell types, except for hematopoietic cells, depending upon the source of MSCs. For example, bone-marrow-derived MSCs (BM-MSCs) can differentiate into osteocytes, hepatocytes, and pancreatic and neuronal cells. MSCs can be isolated from various sources such as bone marrow, placenta, adipose tissue, teeth, and Wharton’s jelly, a gelatinous substance in the umbilical cord. The ease of their...
4.5K
Regulation of Hematopoietic Stem Cells01:01

Regulation of Hematopoietic Stem Cells

3.4K
All blood and immune cells are produced from the multipotent hematopoietic stem cells (HSCs) by the process of hematopoiesis. However, they all have a limited life span. In addition, many are depleted in immune surveillance or combatting an injury or infection. This makes blood one of the most regenerative tissues. Hematopoiesis helps replenish these blood and immune cells, restoring the body's normal functioning. However, overproduction of blood and immune cells can make them cancerous or...
3.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Inflammation and oxidative stress in the sputum of patients with cystic fibrosis: correlations with lung function, aerobic fitness, and morbidity.

Revista paulista de pediatria : orgao oficial da Sociedade de Pediatria de Sao Paulo·2026
Same author

Preclinical safety and anti-inflammatory activity of a standardized Justicia pectoralis Jacq. extract in experimental models of respiratory inflammation.

Journal of ethnopharmacology·2026
Same author

Does ChatGPT know basic human anatomy?

Anatomy & cell biology·2025
Same author

Role of gut microbiota and its functional products in prenatal alcohol-induced anxiety-like behavior.

Progress in neuro-psychopharmacology & biological psychiatry·2025
Same author

Old habits die hard? How to challenge students and professors to rethink the teaching and learning processes in biophysics using escape room-based games.

Advances in physiology education·2025
Same author

The natural compounds derived from the plant Moquiniastrum polymorphum subsp. polymorphum prevent and treat liver fibrosis in vivo by reducing inflammation and fibrotic markers.

Toxicon : official journal of the International Society on Toxinology·2025

Related Experiment Video

Updated: Apr 28, 2026

Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation
07:30

Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation

Published on: June 28, 2024

3.7K

Mesenchymal stem cells decrease splenocytes apoptosis in a sepsis experimental model.

Leonardo Pedrazza1, Adroaldo Lunardelli, Carolina Luft

  • 1Laboratório de Pesquisa em Biofísica Celular e Inflamação, Pontifícia Universidade Católica do Rio Grande do Sul (PUCRS), Avenida Ipiranga 6681, prédio 12, bloco C, sala 221, Porto Alegre, Rio Grande do Sul, CEP 90619-900, Brazil.

Inflammation Research : Official Journal of the European Histamine Research Society ... [Et Al.]
|June 4, 2014
PubMed
Summary

Adipose-derived mesenchymal stem cells (MSCs) significantly reduced mortality in a mouse sepsis model. MSC treatment also decreased inflammatory markers and tissue damage, offering a potential therapeutic strategy for sepsis.

More Related Videos

Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice
06:40

Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice

Published on: February 9, 2014

27.9K
A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
08:04

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

15.7K

Related Experiment Videos

Last Updated: Apr 28, 2026

Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation
07:30

Basement Membrane Matrix Encapsulated Cell Aggregation for Investigating Murine Spleen Tissue Formation

Published on: June 28, 2024

3.7K
Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice
06:40

Cecal Ligation and Puncture-induced Sepsis as a Model To Study Autophagy in Mice

Published on: February 9, 2014

27.9K
A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity
08:04

A Mouse Model of Vascularized Heterotopic Spleen Transplantation for Studying Spleen Cell Biology and Transplant Immunity

Published on: June 11, 2019

15.7K

Area of Science:

  • Immunology
  • Stem Cell Therapy
  • Sepsis Research

Background:

  • Mesenchymal stem cells (MSCs) possess potent immune-modulating properties.
  • Sepsis is a life-threatening condition characterized by a systemic inflammatory response to infection.

Purpose of the Study:

  • To evaluate the efficacy of adipose-derived MSCs in mitigating sepsis in a murine model.
  • To assess the impact of MSCs on immune response, tissue damage, and apoptosis during sepsis.

Main Methods:

  • Three groups of male C57BL/6 mice were used: control, untreated sepsis, and MSC-treated sepsis (1 × 10^6 cells/animal).
  • Mortality rates, tissue damage markers (liver, pancreas), inflammatory markers, and splenocyte apoptosis were analyzed.

Main Results:

  • MSC treatment reduced sepsis-induced mortality from 100% to 40% within 26 hours.
  • MSCs decreased liver and pancreas tissue damage markers and reduced systemic inflammatory markers.
  • MSC treatment inhibited splenocyte apoptosis, a key feature of the untreated septic group.

Conclusions:

  • Adipose-derived MSCs effectively ameliorated the immune response in sepsis.
  • MSC therapy led to decreased inflammatory cytokines and increased anti-inflammatory IL-10.
  • MSCs inhibited splenocyte apoptosis and consequently reduced tissue damage in a sepsis model.