Related Experiment Video

Updated: Apr 28, 2026

Transuterine Fetal Tracheal Occlusion Model in Mice
06:31

Transuterine Fetal Tracheal Occlusion Model in Mice

Published on: February 5, 2021

2.8K

Predictors of early lung function in patients with congenital diaphragmatic hernia

Tiffany Wright1, Amy Filbrun1, Benjamin Bryner1

  • 1University of Michigan, Ann Arbor, MI.

Journal of Pediatric Surgery
|June 4, 2014
PubMed

Insights

Infants with congenital diaphragmatic hernia (CDH) show mild lung function deficits early on. Severity markers like ECMO and prolonged ventilation correlate with reduced lung function in children with CDH.

Area of Science:

  • Pediatric Pulmonology
  • Neonatal Surgery
  • Respiratory Physiology

Background:

  • Congenital diaphragmatic hernia (CDH) can lead to long-term pulmonary issues, including airflow obstruction.
  • Early assessment of lung function in CDH patients is crucial for understanding developmental trajectories.

Purpose of the Study:

  • To identify factors predicting lung function in the first three years of life for infants with CDH.
  • To analyze pulmonary function data in relation to disease severity.

Main Methods:

  • Retrospective analysis of infant pulmonary function testing (IPFT) data from 2006-2012.
  • Utilized raised volume rapid thoracoabdominal compression and plethysmography for IPFT.
  • Included 29 neonates with CDH who underwent IPFT within the first three years of life.

Main Results:

  • Airflow obstruction was the most frequent abnormality (14/29 infants).
  • Extracorporeal membrane oxygenation (ECMO), prolonged ventilation, and oxygen use were significantly associated with restrictive lung disease (p<0.05).
  • Mean predicted survival was 63%±4%, with 48% requiring ECMO.

Conclusions:

  • Children with severe CDH exhibit mild pulmonary deficits in early childhood.
  • Clinical indicators of disease severity, such as ECMO, ventilator duration, and oxygen dependency, are linked to impaired lung function development.
  • Early IPFT provides valuable insights into the pulmonary consequences of CDH.
Abstract

Keywords:
Air flow obstructionAir trappingCongenital diaphragmatic herniaPulmonary functionRestrictive lung disease

More Related Videos

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs05:40

Continuous Telemetric In Utero Tracheal Pressure Measurements in Fetal Lambs

Published on: December 22, 2023

735
Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus06:15

Protocol and Guidelines for Point-of-Care Lung Ultrasound in Diagnosing Neonatal Pulmonary Diseases Based on International Expert Consensus

Published on: March 6, 2019

53.3K

Related Concept Videos

Factors Affecting Pulmonary Ventilation01:19

Factors Affecting Pulmonary Ventilation

Besides the pressure difference between the external environment and the lungs, the airflow rate and ease of pulmonary ventilation are also influenced by three other factors: surface tension of the fluid in the alveoli, compliance of the lungs, and airway resistance.
Alveolar Surface Tension
The alveolar fluid lines the luminal surface of the alveoli and exerts a force called surface tension. This force is caused by the polar water molecules in the liquid being more strongly attracted to each...
3.1K
Pulmonary Cycle: Exhalation01:17

Pulmonary Cycle: Exhalation

In terms of human respiration, the act of expelling air, known as exhalation (or expiration), operates on the principle of pressure gradients. During expiration, the pressure within the lungs exceeds that of the surrounding atmosphere. Under normal conditions, quiet breathing involves passive exhalation and is free of muscular contractions. This is because the exhalation process is driven by the natural elastic recoil of the lungs and chest wall, both of which have an inherent tendency to...
5.0K
Pulmonary Function Tests01:25

Pulmonary Function Tests

Pulmonary Function Tests (PFTs)
Pulmonary Function Tests are crucial diagnostic tools for assessing respiratory function, particularly in patients with chronic respiratory disorders. They comprehensively evaluate lung volumes, ventilatory function, breathing mechanics, diffusion, and gas exchange. These tests help diagnose pulmonary diseases and play a significant role in monitoring disease progression, evaluating disability, and assessing response to therapy.
PFTs involve using a spirometer, a...
1.2K