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[Role of Enterococcus faecium SF 68 in experimental infection in mice]
Abstract:
The normal intestinal flora is an important defence against various infectious agents. It also allows important metabolic stages in the host. The Authors studied the ability of Enterococcus faecium SF 68 to protect the mice (Swiss strain) from infection by Salmonella typhi and its role when used with penicillin in infection by Staphylococcus aureus. Our results showed that SF 68, determined a good protection against infection. Moreover the association E. faecium SF 68-antibiotic lowers the mortality rate in the infected mice compared with the control group.
Insights
Enterococcus faecium SF 68 demonstrated protective effects against Salmonella typhi infection in mice. This probiotic, when combined with antibiotics, also reduced mortality rates in Staphylococcus aureus-infected mice.
Area of Science:
- Microbiology
- Immunology
- Gastroenterology
Background:
- The intestinal flora plays a crucial role in host defense against pathogens.
- Gut microbiota is essential for various metabolic functions within the host.
- Understanding the protective capabilities of specific probiotics is vital for infectious disease management.
Purpose of the Study:
- To evaluate the protective efficacy of Enterococcus faecium SF 68 against Salmonella typhi infection.
- To investigate the role of Enterococcus faecium SF 68 in conjunction with penicillin against Staphylococcus aureus infection.
Main Methods:
- Mice (Swiss strain) were infected with Salmonella typhi to assess Enterococcus faecium SF 68's protective ability.
- Mice were infected with Staphylococcus aureus and treated with a combination of Enterococcus faecium SF 68 and penicillin.
- Mortality rates in treated groups were compared to control groups.
Main Results:
- Enterococcus faecium SF 68 provided significant protection against Salmonella typhi infection.
- The combined administration of Enterococcus faecium SF 68 and antibiotics notably decreased mortality in mice infected with Staphylococcus aureus compared to controls.
Conclusions:
- Enterococcus faecium SF 68 exhibits promising prophylactic and therapeutic potential against bacterial infections.
- The synergistic effect of this probiotic with antibiotics warrants further investigation for clinical applications in combating infectious agents.