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Updated: Apr 28, 2026

Multiplex Therapeutic Drug Monitoring by Isotope-dilution HPLC-MS/MS of Antibiotics in Critical Illnesses
Published on: August 30, 2018
[Self-assessment of patterns of antibiotic use in a university hospital]
J Gómez1, E García-Vázquez1, C Bonillo2
1Servicio de Medicina Interna-Infecciosas, Hospital Clínico Universitario Virgen de la Arrixaca, Murcia, España; Departamento de Medicina, Facultad de Medicina, Universidad de Murcia, Murcia, España.
Introduction:
A questionnaire was used to determine the knowledge, attitudes and practices of antibiotic prescribing among doctors at a university hospital.
Methods:
An anonymous questionnaire was directly distributed by a staff member of the Infectious Diseases Department.
Results:
A total of 316 questionnaires were distributed with 100% response rate; antibiotic dose, route of administration, and treatment duration were always adjusted according to site of infection and underlying conditions in 65, 68 and 45%, respectively. Antibiotic de-escalation was recognized as usual practice in 20%; 31 and 10% considered potential microbiological resistances and economical-cost when taking prescription decisions, respectively; 16% admitted often prescribing antibiotics with no clinical indication. There were no major significant differences between staff and training physicians, or between surgical or medical specialists.
Conclusions:
The self-perception of physicians and residents in our hospital is that they make improper use of antimicrobials.
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