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Updated: Apr 28, 2026

Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists
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Reverse Yeast Two-hybrid System to Identify Mammalian Nuclear Receptor Residues that Interact with Ligands and/or Antagonists

Published on: November 15, 2013

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Role of pregnane X receptor in chemotherapeutic treatment

Wei Zhuo1, Lei Hu, Jinfeng Lv

  • 1Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha, 410008, People's Republic of China.

Cancer Chemotherapy and Pharmacology
|June 4, 2014
PubMed

Insights

Pregnane X receptor (PXR) influences chemotherapy effectiveness and drug interactions by regulating drug metabolism and transport. Understanding PXR

Area of Science:

  • Pharmacology
  • Molecular Biology
  • Oncology

Background:

  • Pregnane X receptor (PXR) is a nuclear receptor superfamily member with varied expression in normal tissues and cancers.
  • PXR activation by endogenous and exogenous substances impacts chemotherapeutic outcomes and drug-drug interactions.
  • Tissue-specific PXR regulation and genetic variants contribute to diverse cancer treatment responses.

Purpose of the Study:

  • To review the role of PXR in anticancer drug metabolism and clearance.
  • To explore PXR-mediated enhancement of chemotherapy.
  • To provide insights into predicting drug-drug interactions and advancing personalized medicine.

Main Methods:

  • Literature review of studies on PXR function in cancer.
  • Analysis of PXR's role in drug metabolism and transport pathways.
  • Examination of PXR's impact on chemotherapy efficacy and toxicity.

Main Results:

  • PXR significantly influences the metabolism and clearance of various anticancer drugs.
  • PXR activation affects drug-drug interactions through modulation of drug-metabolizing enzymes and transporters.
  • Genetic variations in PXR lead to inter-individual differences in chemotherapy response.

Conclusions:

  • PXR plays a critical role in anticancer drug disposition and treatment outcomes.
  • Targeting PXR may offer strategies for enhancing chemotherapy efficacy and managing drug interactions.
  • Further research into PXR is crucial for developing personalized cancer therapies.

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