Transport and Golgi organisation protein 1 is a novel tumour progressive factor in oral squamous cell carcinoma

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Tomonori Sasahira1, Tadaaki Kirita2, Kazuhiko Yamamoto2

  • 1Department of Molecular Pathology, Nara Medical University, 840 Shijo-cho, Kashihara 634-8521, Japan.

European Journal of Cancer (Oxford, England : 1990)
|June 4, 2014
PubMed

Insights

Transport and Golgi organisation protein 1 (TANGO) promotes oral cancer progression and metastasis by enhancing blood and lymph vessel formation. TANGO expression in oral squamous cell carcinoma (OSCC) correlates with worse patient survival, suggesting it as a potential therapeutic target.

Area of Science:

  • Oncology
  • Molecular Biology
  • Cancer Research

Background:

  • The role of the melanoma inhibitory activity (MIA) gene family in cancer is controversial, with some members acting as oncogenes and others as tumor suppressors.
  • Transport and Golgi organisation protein 1 (TANGO), also known as MIA3, has shown tumor-suppressive functions in some cancers, but its role in oral squamous cell carcinoma (OSCC) was unclear.

Purpose of the Study:

  • To investigate the expression and function of TANGO in oral squamous cell carcinoma (OSCC).
  • To determine the correlation between TANGO expression and clinicopathological parameters in OSCC.
  • To elucidate the potential mechanisms by which TANGO influences OSCC progression.

Main Methods:

  • Analysis of TANGO expression in human OSCC cell lines.
  • Immunohistochemical examination of TANGO in 171 primary OSCC cases.
  • Statistical assessment of TANGO expression with clinicopathological parameters, including vessel density.
  • TANGO knockdown experiments in OSCC cells to evaluate effects on growth, invasion, and apoptosis.
  • Investigation of TANGO's influence on platelet-derived growth factor beta polypeptide (PDGFB) and Neuropilin2 activities.

Main Results:

  • TANGO expression was detected in 35.1% of OSCC cases.
  • TANGO knockdown in OSCC cells inhibited cell growth and invasion, and induced apoptosis.
  • TANGO knockdown led to the inhibition of platelet-derived growth factor beta polypeptide (PDGFB) and Neuropilin2 activities.
  • TANGO expression was significantly associated with tumor progression, nodal metastasis, clinical stage, and increased blood and lymph vessel density.
  • Patients with TANGO expression exhibited significantly worse disease-free survival compared to those without TANGO expression.

Conclusions:

  • TANGO plays a pro-tumorigenic role in OSCC, promoting tumor progression and metastasis.
  • TANGO may promote angiogenesis and lymphangiogenesis in OSCC, potentially through the upregulation of PDGFB and Neuropilin2.
  • TANGO expression is a potential prognostic biomarker for OSCC and a possible therapeutic target.
Keywords:
AngiogenesisLymphangiogenesisMIANeuropilin2Oral cancerPDGFBTANGO

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