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Related Concept Videos

Epigenetic Regulation01:46

Epigenetic Regulation

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Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
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Epigenetic Regulation01:37

Epigenetic Regulation

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Epigenetic changes alter the physical structure of the DNA without changing the genetic sequence and often regulate whether genes are turned on or off. This regulation ensures that each cell produces only proteins necessary for its function. For example, proteins that promote bone growth are not produced in muscle cells. Epigenetic mechanisms play an essential role in healthy development. Conversely, precisely regulated epigenetic mechanisms are disrupted in diseases like cancer.
X-chromosome...
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Genomic Imprinting and Inheritance02:30

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Diploid organisms inherit genetic material through chromosomes from both parents. Copies of the same gene are known as alleles. In most cases, both alleles are simultaneously expressed and allow various cellular processes to function optimally. If one of the alleles is missing or mutated, the expression of the other allele can compensate; however, this is not true for all genes.
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Inheritance of Chromatin Structures03:17

Inheritance of Chromatin Structures

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Epigenetics is the study of inherited changes in a cell's phenotype without changing the DNA sequences. It provides a form of memory for the differential gene expression pattern to maintain cell lineage, position-effect variegation, dosage compensation, and maintenance of chromatin structures such as telomeres and centromeres. For example, the structure and location of the centromere on chromosomes are epigenetically inherited. Its functionality is not dictated or ensured by the underlying...
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Combinatorial Gene Control02:33

Combinatorial Gene Control

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Combinatorial gene control is the synergistic action of several transcriptional factors to regulate the expression of a single gene. The absence of one or more of these factors may lead to a significant difference in the level of gene expression or repression.
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Related Experiment Video

Updated: Apr 28, 2026

Author Spotlight: Achieving High-Purity In Vitro Differentiation of Th17 Cells Using Cytokine Concentration Modulation
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Epigenetic control of immunity.

Meinrad Busslinger1, Alexander Tarakhovsky2

  • 1Research Institute of Molecular Pathology, Vienna Biocenter, A-1030 Vienna, Austria.

Cold Spring Harbor Perspectives in Biology
|June 4, 2014
PubMed
Summary

Immune cell diversity and plasticity are crucial for responding to pathogens. Epigenetic processes regulate these immune cell functions, impacting health and disease.

Area of Science:

  • Immunology
  • Cell Biology
  • Epigenetics

Background:

  • Immunity depends on diverse immune cells with adaptable responses to pathogens.
  • Adaptive immunity uses diverse antigen receptors, while innate immunity relies on cell heterogeneity and plasticity.
  • Immune responses are modulated by graded cell activity, from proliferation to dormancy.

Purpose of the Study:

  • To describe key epigenetic processes in immune cell function.
  • To highlight the role of epigenetics in immune responses during health and disease.

Main Methods:

  • Review of key epigenetic mechanisms.
  • Analysis of immune cell heterogeneity and plasticity.
  • Discussion of epigenetic regulation in adaptive and innate immunity.

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Main Results:

  • Epigenetic processes are fundamental to immune cell function and response.
  • Cellular heterogeneity and plasticity are regulated by epigenetic mechanisms.
  • Epigenetic regulation influences immune cell activity across a spectrum from proliferation to dormancy.

Conclusions:

  • Epigenetic mechanisms are critical regulators of immune cell function.
  • Understanding these processes is vital for addressing immune-related health and disease conditions.