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Biological activities of synthetic polypeptides containing a repetitive core sequence (Arg-Gly-Asp) of cell adhesion

I Saiki¹, J Iida, I Azuma

¹Institute of Immunological Science, Hokkaido University, Sapporo, Japan.

International Journal of Biological Macromolecules

|February 1, 1989

Abstract:

A unique polypeptide containing the repeated structure of core sequence from cell adhesion molecules, poly(Arg-Gly-Asp), was successfully prepared by the polymerization procedure with diphenylphosphoryl azide. This polypeptide dramatically inhibited the aggregation of platelets induced by adenosine diphosphate (ADP) or malignant melanoma cells.

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