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Posaconazole concentrations in human tissues after allogeneic stem cell transplantation
Ola Blennow1, Erik Eliasson2, Tommy Pettersson2
1Department of Infectious Diseases, Karolinska University Hospital, Stockholm, Sweden Centre for Allogeneic Stem Cell Transplantation, Karolinska University Hospital, Stockholm, Sweden ola.blennow@karolinska.se.
Abstract:
Few data have been published regarding posaconazole tissue concentrations in humans. We analyzed tissue concentrations in biopsy specimens taken at autopsy from seven patients who received posaconazole prophylaxis because of graft-versus-host disease. The results were compared to plasma concentrations collected before death. Tissue concentrations suggestive of an accumulation of posaconazole were found in the heart, lung, liver, and kidney but not in the brain.
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