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Updated: Apr 28, 2026

Amide Coupling Reaction for the Synthesis of Bispyridine-based Ligands and Their Complexation to Platinum as Dinuclear Anticancer Agents
Published on: May 28, 2014
Cooperative complexation of amino acid derivatives to platinum acetylide-based bolaamphiphile
Yu-Jing Tian1, En-Tai Shi, Yu-Kui Tian
1School of Medical Engineering, Hefei University of Technology , Hefei, Anhui 230009, P. R. China.
Abstract:
A platinum(II) acetylide-based bolaamphiphile equipped with two peripheral B18C6 moieties has been successfully prepared, which demonstrates cooperative recognition behavior toward l-alanine ester salt in chloroform. In a polar methanol/chloroform (3/1, v/v) medium, the amino acid additives influence the aggregation of the bolaamphiphile significantly, leading to the morphological transition from nanospherical to disordered structures. The adaptive properties of the current host-guest binary system will benefit the development of stimuli-responsive supramolecular materials.
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