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Updated: Apr 28, 2026
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Generation of 3D Skin Organoid from Cord Blood-derived Induced Pluripotent Stem Cells
Published on: April 18, 2019
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Cell therapy in dermatology
Gabriela Petrof1, Alya Abdul-Wahab1, John A McGrath1
1St. John's Institute of Dermatology, King's College London (Guy's Campus), London SE1 1UL, United Kingdom.
Cold Spring Harbor Perspectives in Medicine
|June 4, 2014
Summary
Cell therapy using skin cells offers new treatments for inherited and acquired skin disorders. Research explores stem cells and other sources for improved skin regeneration and wound healing in dermatology.
Area of Science:
- Regenerative Medicine
- Dermatology
- Cell Biology
Background:
- Human skin cells, keratinocytes and fibroblasts, possess regenerative potential.
- Existing cell-based therapies and bioengineered skin products are used for skin disorders.
- Clinical trials are ongoing for novel cell therapy products.
Purpose of the Study:
- To review preclinical and clinical studies on cell therapy in dermatology.
- To explore future directions for cell-based treatments in skin disorders.
- To focus on inherited skin diseases with fragile skin and poor wound healing.
Main Methods:
- Review of preclinical and clinical studies.
- Investigation of extracutaneous cell sources (e.g., bone marrow).
- Exploration of stem cell technologies like inducible pluripotent stem cells.
Main Results:
- Cultured cells and bioengineered skin are utilized in current treatments.
- Extracutaneous cell sources show potential for skin regeneration.
- Stem cell strategies offer promising future therapeutic avenues.
Conclusions:
- Cell therapy holds significant promise for treating various skin disorders.
- Ongoing research and clinical trials are advancing the field of dermatological cell therapy.
- Future strategies involving stem cells could revolutionize skin regeneration therapies.
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