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Kidney cancer: bisphosphonates in the era of antiangiogenic targeted therapy

Frederik C Roos1

  • 1Department of Urology, Medical School, Johannes Gutenberg University, Langenbeckstrasse 1, Mainz 55131, Germany.

Nature Reviews. Urology
|June 4, 2014
PubMed

Insights

Bisphosphonates are approved for metastatic renal cell carcinoma bone pain and skeletal events. However, new research indicates they do not improve survival or prevent these skeletal-related events.

Area of Science:

  • Oncology
  • Bone Metastasis Research

Background:

  • Bone is a frequent metastatic site in renal cell carcinoma.
  • Bisphosphonates are commonly used to manage bone complications.

Purpose of the Study:

  • To evaluate the efficacy of bisphosphonates in improving survival and preventing skeletal-related events (SREs) in metastatic renal cell carcinoma patients.

Main Methods:

  • Review of existing research and clinical data on bisphosphonate use in this patient population.

Main Results:

  • Current evidence suggests bisphosphonates do not significantly improve overall survival.
  • Bisphosphonates may not effectively prevent the development of skeletal-related events.

Conclusions:

  • The established benefits of bisphosphonates for survival and SRE prevention in metastatic renal cell carcinoma require re-evaluation.
  • Further research is needed to explore alternative or supplementary treatments for bone metastases in renal cell carcinoma.

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