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An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection
09:01

An In vitro Model to Study Immune Responses of Human Peripheral Blood Mononuclear Cells to Human Respiratory Syncytial Virus Infection

Published on: December 10, 2013

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[Respiratory syncitial virus in immunocompromised patients in a pediatric hospital: 5 years experience]

N Domínguez-Pinilla1, S Belda Hofheinz2, J L Vivanco Martinez1

  • 1Unidad de Hemato-Oncología Pediátrica, Hospital 12 de Octubre, Madrid, España.

Anales De Pediatria (Barcelona, Spain : 2003)
|June 4, 2014
PubMed

Insights

Respiratory syncytial virus (RSV) can cause severe illness in immunocompromised children. This study reviewed pediatric cases, finding that while some required intensive care, no deaths occurred during the study period.

Area of Science:

  • Pediatric Infectious Diseases
  • Immunocompromised Host Pathogens

Background:

  • Respiratory syncytial virus (RSV) infection poses significant risks to immunocompromised individuals, increasing morbidity and mortality.
  • Pediatric populations with compromised immune systems are particularly vulnerable to severe RSV outcomes.

Purpose of the Study:

  • To describe the clinical characteristics and outcomes of RSV infections in immunocompromised pediatric patients.
  • To evaluate the severity and management of RSV in specific pediatric units.

Main Methods:

  • Retrospective case series analysis of immunocompromised pediatric patients diagnosed with RSV.
  • Data collected from Hematology and Oncology and Immunodeficiency Units between 2008 and 2012.

Main Results:

  • Nineteen pediatric patients were diagnosed with RSV infection.
  • Nine patients required hospitalization, and two needed Pediatric Intensive Care Unit (PICU) admission.
  • Five patients received specific antiviral therapy, including ribavirin and/or palivizumab; no deaths were reported.

Conclusions:

  • RSV infection can manifest severely in immunocompromised pediatric patients.
  • Prompt diagnosis and potential specific therapies may mitigate severe outcomes, including mortality.
Abstract

Keywords:
ECMOImmunocompromised HostInmunodeprimidoPalivizumabRespiratory syncytial virusRibavirinRibavirinaVirus respiratorio sincitial

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