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Using Mouse Mammary Tumor Cells to Teach Core Biology Concepts: A Simple Lab Module
Published on: June 18, 2015
Soil amendments that slow cancer growth
Clare M Isacke1, Mary Helen Barcellos-Hoff2
1Authors' Affiliations:Breakthrough Breast Cancer Research Centre, The Institute of Cancer Research, London, United Kingdom; and Departments of Radiation Oncology and Cell Biology, New York University School of Medicine, New York, New York.
Abstract:
The recognition that the tumor microenvironment contributes to tumor survival, growth, and response to therapy provides the rationale for considering it a therapeutic target. The article by Alspach and colleagues in this issue provides evidence that p38MAPK acts posttranscriptionally to promote the tumor-permissive secretory phenotype of both cancer-associated and senescent fibroblasts, and that p38MAPK inhibitors already in clinical trials have significant therapeutic potential.
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