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The tumor-associated marker, PVRL4 (nectin-4), is the epithelial receptor for morbilliviruses

Sebastien Delpeut1, Ryan S Noyce2, Christopher D Richardson3

  • 1The Department of Microbiology and Immunology, Dalhousie University, Halifax, B3H 1X5 NS, Canada. sebastien.delpeut@dal.ca.

Viruses
|June 4, 2014
PubMed

Insights

Poliovirus receptor-like 4 (PVRL4) is the epithelial receptor for morbilliviruses. Measles virus, using PVRL4, can target and destroy lung, breast, and ovarian adenocarcinomas expressing this tumor marker.

Area of Science:

  • Virology
  • Oncology
  • Cell Biology

Background:

  • Poliovirus receptor-like 4 (PVRL4), also known as nectin-4, is identified as the epithelial receptor for Morbillivirus.
  • Morbilliviruses include measles virus, canine distemper virus, and peste des petits ruminants virus.

Purpose of the Study:

  • To describe the role of PVRL4 in morbillivirus pathogenesis.
  • To explore the potential of PVRL4 as a target for cancer therapies.

Main Methods:

  • The study investigates the interaction between PVRL4 and morbilliviruses.
  • It examines the expression of PVRL4 in various adenocarcinoma types.

Main Results:

  • PVRL4 facilitates virus spread from lymphocytes to airway epithelial cells.
  • PVRL4 is a known tumor-associated marker in lung, breast, and ovarian adenocarcinomas.

Conclusions:

  • PVRL4 plays a critical role in morbillivirus pathogenesis and transmission.
  • Measles virus, by targeting PVRL4, shows promise as an oncolytic agent against specific adenocarcinomas.

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