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Published on: September 15, 2017
Association between urine aldosterone and diastolic function in patients with primary aldosteronism and essential
Yi-Yao Chang1, Hsiu-Hao Lee2, Chi-Sheng Hung3
1Cardiology Division of Cardiovascular Medical Center, Far Eastern Memorial Hospital, New Taipei City, Taiwan.
Objective:
To investigate the association between aldosterone and cardiac diastolic dysfunction.
Design And Methods:
We prospectively enrolled 20 patients with primary aldosteronism (PA) and 22 patients with essential hypertension (EH). Plasma aldosterone concentration, plasma renin activity, and 24-h urine aldosterone level were measured. Echocardiography, including tissue Doppler image recordings, was performed.
Results:
PA patients had a significantly higher left ventricular (LV) mass index and worse LV diastolic function than those in EH patients. Among various measures of aldosterone, log-transformed 24-h urine aldosterone level had the most consistent correlation with diastolic function.
Conclusions:
Aldosterone is strongly associated with LV diastolic dysfunction. Twenty-four hour urine aldosterone is a good indicator to evaluate the impact of aldosterone on LV diastolic function.
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