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Cancer immunotherapeutics: evolution of monoclonal antibodies to peptide immunogens

Ramachadran Murali1, Thomas Kieber-Emmons

  • 11 Department of Biological Sciences, Cedars-Sinai Medical Center , Los Angeles, California.

Monoclonal Antibodies in Immunodiagnosis and Immunotherapy
|June 4, 2014
PubMed

Insights

The Wistar Institute pioneered biotechnology, validating monoclonal antibodies for therapeutics. This success paves the way for future cancer vaccines, building on their infectious disease vaccine expertise.

Area of Science:

  • Biotechnology and Life Sciences
  • Biopharmaceutical Sector
  • Vaccinology

Background:

  • The Wistar Institute, under Hilary Koprowski, excelled in translating basic science into clinical applications via biotechnology and life science enterprises.
  • Koprowski's early insights into monoclonal antibodies (mAbs) have been largely validated, with mAb therapeutics representing a rapidly expanding, successful, and profitable segment of the biopharmaceutical industry.
  • Over 30 mAb drugs are now approved in the US and Europe, highlighting their therapeutic significance.

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