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Updated: Apr 28, 2026

Microwave-Assisted Preparation of 1-Aryl-1H-pyrazole-5-amines
Published on: June 23, 2019
Synthesis, biological evaluation and molecular modeling study of pyrazole derivatives as selective COX-2 inhibitors
Ashish Kumar Tewari1, Ved Prakash Singh1, Pratima Yadav1
1Department of Chemistry, Faculty of Science, Banaras Hindu University, Varanasi 221 005, India.
Abstract:
A novel series of pyrazole derivatives were synthesized and evaluated in vivo for their anti-inflammatory activity in carrageenan-induced rat paw edema model. Among all compounds, 5a, and 5b showed comparable anti-inflammatory activity to Nimesulide, the standard drug taken for the studies. In silico (docking) studies were carried out to investigate the theoretical binding mode of the compounds to target the cyclooxygenase (COX-2) using Autodock 4.2.
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