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Most common HCV genotypes in patients from north-eastern Croatia

Magdalena Perić1, Zinka Bošnjak, Snježana Džijan2

  • 1Institute of Public Health Osijek, F. Krežme 1, 31 000 Osijek, Croatia. zinkahr@gmail.com.

Acta Medica Academica
|June 5, 2014
PubMed

Insights

Hepatitis C virus (HCV) RNA was detected in 61.1% of antibody-positive patients, with genotype 1 being most common, particularly in older individuals. Early RNA detection is crucial for managing Hepatitis C virus disease.

Area of Science:

  • Hepatology
  • Virology
  • Public Health

Background:

  • Hepatitis C virus (HCV) infection remains a significant global health concern.
  • Understanding viral load, genotype distribution, and risk factors is crucial for effective management and treatment strategies.

Purpose of the Study:

  • To determine Hepatitis C virus RNA viral load, genotype distribution, risk factors, and symptoms in HCV antibody-positive patients in north-eastern Croatia.
  • To assess the correlation between patient demographics, risk factors, and HCV RNA positivity.

Main Methods:

  • Analysis of 203 HCV antibody-positive patients (January 2009-December 2011) using COBAS TaqMan HCV and Linear Array HCV Genotyping tests.
  • Structured questionnaires collected data on risk factors and symptoms.

Main Results:

  • HCV RNA prevalence was 61.1%, increasing with age (73% in >50 years vs. 55% in 20-50 years).
  • Genotype 1 was predominant (79.8%), associated with older patients (median age 50).
  • Blood transfusions before 1993 were significantly linked to HCV RNA positivity.

Conclusions:

  • Elevated prevalence of genotype 1 in elderly HCV RNA-positive patients suggests a potential rise.
  • RNA-based detection in antibody-positive individuals enables early identification of acute Hepatitis C virus infection.
  • Early detection can mitigate the risk of genotype-related treatment failure.
Abstract

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