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Influence of inhalation injury on energy expenditure in severely burned children

Rene Przkora1, Ricki Y Fram2, David N Herndon2

  • 1Department of Surgery, University of Texas Medical Branch, Galveston, TX, United States; Shriners Hospitals for Children, Galveston, TX, United States; Department of Anesthesiology, University of Texas Medical Branch, Galveston, TX, United States.

Burns : Journal of the International Society for Burn Injuries
|June 5, 2014
PubMed

Insights

Inhalation injury does not worsen the hypermetabolic stress response in children with severe burns. Resting energy expenditure and oxygen consumption remain unaffected, indicating no additional metabolic burden.

Area of Science:

  • Pediatric critical care medicine
  • Burn management
  • Metabolic response to injury

Background:

  • Severe burns trigger a hypermetabolic state, increasing energy demands.
  • Inhalation injury is a common complication in pediatric burn patients.
  • The impact of inhalation injury on burn hypermetabolism is not fully understood.

Purpose of the Study:

  • To determine if inhalation injury exacerbates burn-induced hypermetabolism in children.
  • To compare metabolic parameters in burned children with and without inhalation injury.

Main Methods:

  • Prospective study involving 86 children (1-18 years) with ≥40% total body surface area burns.
  • Stratified patients into groups with and without inhalation injury, diagnosed via bronchoscopy.
  • Measured resting energy expenditure and oxygen consumption during acute hospitalization.

Main Results:

  • No significant differences in resting energy expenditure or percent of predicted basal metabolic rate between groups.
  • Oxygen consumption did not differ significantly between children with and without inhalation injury.
  • Patients with inhalation injury had significantly lower PaO2:FiO2 ratios on admission.

Conclusions:

  • Inhalation injury does not augment the hypermetabolic stress response in pediatric burn patients.
  • Resting energy expenditure and oxygen consumption are not significantly affected by inhalation injury in this population.
Abstract

Keywords:
BurnsHypermetabolismIndirect calorimetryInhalation injuryOxygen consumptionResting energy expenditure

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