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Related Experiment Video

Updated: Apr 28, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

Published on: October 14, 2016

Advances in therapy for pediatric sarcomas.

Aaron Weiss¹, Jonathan Gill, John Goldberg

¹Division of Pediatric Hematology-Oncology, Maine Medical Center, 22 Bramhall Street, Portland, ME, 04102, USA, WEISSA2@mmc.org.

Current Oncology Reports

|June 5, 2014

Summary

Pediatric sarcomas, rare cancers, are treated with combination chemotherapy and local control. Advances focus on risk stratification, cooperative trials, and novel therapies like epigenetics and immunotherapy for better outcomes.

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Last Updated: Apr 28, 2026

Establishment of Cancer Stem Cell Cultures from Human Conventional Osteosarcoma

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Published on: October 14, 2016

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

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A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

A Mouse Model of Incompletely Resected Soft Tissue Sarcoma for Testing Neoadjuvant Therapies

Published on: July 28, 2020

Area of Science:

Pediatric Oncology
Medical Research
Cancer Therapy

Background:

Pediatric sarcomas are rare individual cancers but common as a group.
Current treatments involve combination chemotherapy and local control measures.
Achieving sustained remission in metastatic disease remains challenging.

Purpose of the Study:

To review recent advancements in understanding pediatric sarcoma.
To highlight ongoing and future cooperative group clinical trials.
To discuss emerging therapeutic strategies for pediatric sarcomas.

Main Methods:

Review of current literature and clinical trial data.
Focus on cooperative group efforts in defining risk and treatment.
Exploration of novel therapeutic modalities.

Main Results:

Clinical trials have improved risk stratification and treatment delivery.
Local disease control is often curative but associated with morbidity.
Metastatic disease remains difficult to cure, necessitating new approaches.

Conclusions:

Continued collaboration in clinical trials is crucial for pediatric sarcoma research.
Emerging therapies like epigenetics and immunotherapy show promise.
Advancing treatment strategies aim to improve cure rates and reduce long-term morbidities.