Effect of exercise on cardiac and metabolic outcomes in people living with HIV

Insights

Exercise may help people with HIV manage cardiovascular disease risk factors. This review examines aerobic and resistance training impacts on metabolic and heart health in people living with HIV (PLWH).

Area of Science:

  • Cardiology
  • Infectious Diseases
  • Exercise Science

Background:

  • Poorly controlled HIV infection and antiretroviral therapy, particularly protease inhibitors, increase cardiovascular disease (CVD) risk in people living with HIV (PLWH).
  • Lifestyle factors (smoking, inactivity, poor diet) and psychosocial elements (stress, trauma, depression) exacerbate CVD risk in PLWH.

Purpose of the Study:

  • To critically evaluate recent aerobic and resistance exercise studies.
  • To assess the impact of exercise on cardiovascular and metabolic risk factors in PLWH.

Main Methods:

  • Systematic review of recent exercise intervention studies.
  • Analysis of cardiovascular and metabolic outcomes in people living with HIV.

Main Results:

  • Emerging evidence suggests exercise interventions can positively influence CVD risk factors in PLWH.
  • Specific impacts on lipid profiles, inflammation, and body composition require further investigation.

Conclusions:

  • Aerobic and resistance exercise show promise for mitigating cardiovascular and metabolic risks in people living with HIV.
  • Further research is needed to optimize exercise protocols and long-term benefits for PLWH.

Related Concept Videos

Exercise and Cardiovascular Response01:20

Exercise and Cardiovascular Response

Exercise significantly impacts cardiovascular response, which is crucial for understanding patient health and designing effective treatment plans.
Light to moderate physical activity initiates a series of interconnected responses in the body. The heart rate modestly increases in anticipation of the workout, followed by widespread vasodilation as oxygen consumption by skeletal muscles increases. This results in decreased peripheral resistance, increased capillary blood flow, and accelerated...
6.6K
Exercise and Cardiac Output01:17

Exercise and Cardiac Output

Regular physical activity is essential for maintaining cardiovascular health, with aerobic exercises being particularly effective. According to the American Heart Association, 150 minutes of moderate to intense aerobic exercise per week is recommended for a healthy heart. Aerobic activities may include brisk walking, running, bicycling, cross-country skiing, and swimming, ideally performed three to five times per week.
Sustained exercise increases the muscles' oxygen demand, which can be...
3.8K
Cardiac Output I:Effect of Heart Rate on Cardiac Output01:19

Cardiac Output I:Effect of Heart Rate on Cardiac Output

Cardiac Output
Cardiac output (CO) refers to the total amount of blood ejected by one of the ventricles in liters per minute (L/min). In a resting adult, CO ranges from 5 to 6 L/min, adjusting according to the body's metabolic requirements.
Effect of Heart Rate on Cardiac Output
Cardiac output adapts to metabolic demands during stress, physical activity, or illness. The autonomic nervous system regulates heart rate via the sinoatrial node. The parasympathetic nervous system decreases heart...
3.4K
Pathophysiology of Cardiac Performance01:29

Pathophysiology of Cardiac Performance

Typical heart performance is influenced by heart rate, rhythm, myocardial contraction, and metabolism or blood flow. The cardiac muscle exhibits distinct electrophysiological features, including pacemaker activity and calcium channel control, which play a vital role in the heart's response to various drugs. The autonomic nervous system, comprising the sympathetic and parasympathetic branches, regulates heart rate. Sympathetic activation increases heart rate, while parasympathetic activation...
2.2K
Heart Failure II: Pathophysiology01:29

Heart Failure II: Pathophysiology

Systolic Heart Failure and Compensatory MechanismsSystolic heart failure (also termed HFrEF, Heart Failure with Reduced Ejection Fraction) is the most prevalent type of heart filure. It results in a decreased volume of blood being pumped from the ventricle. The aortic arch and carotid sinuses have baroreceptors that detect reduced blood pressure, triggering the sympathetic nervous system (SNS) to release epinephrine and norepinephrine. Initially, this response aims to boost heart rate and...
1.7K
Exercise Stress Test01:26

Exercise Stress Test

Introduction
Exercise stress testing, commonly known as a treadmill test, is a noninvasive procedure used to evaluate cardiovascular function and diagnose heart conditions.
Definition
An exercise stress test measures the heart's response to exertion using a treadmill or stationary bicycle. Chest electrodes record the heart's electrical activity through an ECG, and blood pressure is monitored regularly.
Purposes
2.3K