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Updated: Apr 28, 2026

Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes

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Published on: June 13, 2014

Galectins: major signaling modulators inside and outside the cell.

D Compagno, F M Jaworski, L Gentilini

¹Laboratorio de Glicómica Funcional, IQUIBICEN-CONICET, Departamento de Química Biológica, Facultad de Ciencias Exactas y Naturales, Universidad de Buenos Aires, C1428, Ciudad de Buenos Aires, Argentina. diegoladerach@qb.fcen.uba.ar.

Current Molecular Medicine

|June 5, 2014

Summary

Galectins regulate cell behavior through signaling pathways. This review explores galectin functions, glycan interactions, and cellular locations to understand their impact and guide therapeutic strategies.

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Area of Science:

Cell Biology
Glycobiology
Molecular Signaling

Background:

Galectins are key regulators of cellular functions via signaling pathways.
Their biological activities often depend on recognizing extracellular glycans and forming multivalent interactions.
Intracellular galectin roles and signaling mechanisms remain incompletely understood.

Purpose of the Study:

To review current knowledge on galectin-activated signaling pathways.
To elucidate the role of glycan dependence in galectin function.
To identify cellular compartments where galectins exert biological relevance.

Main Methods:

Literature review and synthesis of existing research on galectin signaling.
Analysis of studies investigating galectin-glycan interactions.
Examination of evidence for intracellular and extracellular galectin functions.

Main Results:

Galectins activate diverse signaling cascades influencing cell behavior.
Glycan recognition and multivalent binding are crucial for many galectin-mediated responses.
Galectins function in various cellular compartments, with distinct roles yet to be fully defined.

Conclusions:

Understanding the complete galectin signalosome is vital for manipulating galectin expression and function.
Further research into intracellular galectin mechanisms is essential.
Targeting galectin pathways offers potential therapeutic avenues.