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Updated: Apr 28, 2026

Inducing Plasticity of Astrocytic Receptors by Manipulation of Neuronal Firing Rates
Published on: March 20, 2014
The impact of receptor-receptor interactions in heteroreceptor complexes on brain plasticity
Kjell Fuxe1, Luigi F Agnati, Dasiel O Borroto-Escuela
1Department of Neuroscience, Division of Cellular and Molecular Neurochemistry, Karolinska Institutet, 17177 Stockholm, Sweden.
Abstract:
Allosteric mechanisms in receptor heteromers markedly increase the repertoire of receptor recognition and signaling. Of high importance is the altered function in the receptor heteromer versus the receptor homomer. Such a change in receptor function is mainly brought about by agonist induced allosteric receptor-receptor interactions and leads to functional and structural plasticity. Receptor-receptor interactions integrating synaptic and volume transmission signals participate in a significant way in modulating bidirectional synaptic plasticity and thus Hebbian plasticity. One molecular mechanism that can contribute to a change of synaptic weight may be represented by multiple interactions between plasma membrane receptors forming higher order heteroreceptor complexes via oligomerization at the pre- and post-junctional level. Such long-lived heteroreceptor complexes may play a significant role in learning and memory.
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