Related Experiment Video

Updated: Apr 28, 2026

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA
12:18

Subcutaneous Infection of Methicillin Resistant Staphylococcus Aureus MRSA

Published on: February 9, 2011

22.2K

Refractory pyoderma gangrenosum in an infant

Chloe Etzler1, Sarah Cannon, Patrice Hyde

  • 1Jefferson Medical College, Philadelphia, PA.

Pediatric Dermatology
|June 5, 2014
PubMed

Insights

This case study details a rare instance of infantile pyoderma gangrenosum, a severe skin condition, that persisted despite various treatments. The cause of this prolonged and treatment-resistant condition remains unknown, highlighting a diagnostic challenge.

Area of Science:

  • Dermatology
  • Pediatrics
  • Rare Diseases

Background:

  • Pyoderma gangrenosum (PG) is a rare, ulcerative neutrophilic dermatosis.
  • Infantile PG is exceptionally uncommon, presenting diagnostic and therapeutic challenges.
  • Understanding the etiology of idiopathic PG is crucial for effective management.

Observation:

  • A rare case of infantile pyoderma gangrenosum is presented.
  • The condition exhibited an unusually extended clinical course.
  • The patient showed limited responsiveness to multiple therapeutic interventions.

Findings:

  • Extensive investigations failed to identify any underlying systemic disorder.
  • The infantile pyoderma gangrenosum case was classified as idiopathic.
  • This case underscores the complexity of managing treatment-resistant pediatric dermatoses.

Implications:

  • This case highlights the need for further research into the pathogenesis of idiopathic infantile pyoderma gangrenosum.
  • It emphasizes the importance of considering rare dermatological conditions in pediatric patients with non-responsive skin lesions.
  • Improved diagnostic and therapeutic strategies are needed for this challenging condition.

More Related Videos

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis08:46

A Neonatal Imaging Model of Gram-Negative Bacterial Sepsis

Published on: August 12, 2020

5.5K
A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis07:22

A Standardized Procedure of Dressing Management for Toxic Epidermal Necrolysis

Published on: March 14, 2025

1.4K

Related Concept Videos

Acute Pyelonephritis II: Diagnostic Studies and Management01:28

Acute Pyelonephritis II: Diagnostic Studies and Management

Introduction:For diagnosing acute pyelonephritis, a comprehensive patient history is collected to identify symptoms such as dysuria, frequent or urgent urination, flank pain, or costovertebral angle (CVA) tenderness that may suggest a kidney infection.Physical ExaminationDuring the physical examination, CVA tenderness is assessed. This involves gentle percussion over the costovertebral angle, where tenderness often indicates a kidney infection.Diagnostic TestsUrinalysis: Used to identify white...
835
Acute Pyelonephritis I: Introduction01:27

Acute Pyelonephritis I: Introduction

Pyelonephritis is a bacterial infection that primarily affects the renal parenchyma and collecting system, including the renal pelvis, tubules, and interstitial tissue of one or both kidneys. It can be classified as either acute—a sudden, severe infection—or chronic, which refers to long-term or recurrent kidney infections.The primary cause of acute pyelonephritis (APN) is bacterial infection, with Escherichia coli accounting for approximately 70-80% of cases. Other bacteria, such...
1.5K
Staphylococcal Skin Infections01:29

Staphylococcal Skin Infections

Staphylococcus aureus is a Gram-positive coccus that resides harmlessly on the skin and mucous membranes of healthy individuals. When the skin barrier is breached, it can shift from a commensal to an opportunistic pathogen. This transition is facilitated by surface adhesins, such as clumping factor B and S. aureus surface protein G (SasG), which bind to structural proteins, including loricrin and cytokeratin, in the damaged epidermis. Protein A, another key factor, binds the Fc region of...
138
Rheumatic Heart Disease I: Introduction01:23

Rheumatic Heart Disease I: Introduction

Rheumatic heart disease or RHD is a chronic condition that results from rheumatic fever, causing permanent damage to the heart valves.Etiology and Risk FactorsIt primarily arises from rheumatic fever, an inflammatory disease that can develop after untreated or inadequately treated group A streptococcal (GAS) pharyngitis. Streptococcus spreads through direct contact with oral or respiratory secretions. While the bacteria are the causative agents, factors like malnutrition, overcrowding, poor...
1.0K