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Related Concept Videos

Single Nucleotide Polymorphisms-SNPs01:05

Single Nucleotide Polymorphisms-SNPs

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A single nucleotide polymorphism or SNP is a single nucleotide variation at a specific genomic position in a large population. It is the most prevalent type of sequence variation found in the human genome. Point mutations that occur in more than 1% of the population qualify as SNPs. These are present once every 1000 nucleotides on an average in the human genome. Replacement of a purine with another purine (A/G) or a pyrimidine with another pyrimidine (C/T) is known as a transition. In contrast,...
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Sequencing of the human genome has opened up several best-kept secrets of the genome. Scientists have identified thousands of genome variations that exist within a population. These variations can be a single nucleotide or a larger chromosomal variation.
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Genes usually encode proteins necessary for the proper functioning of a healthy cell. Mutations can often cause changes to the gene expression pattern, thereby altering the phenotype.
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CD24 single nucleotide polymorphisms and cancer risk.

Shushan Yan1, Donghua Xu, Tao Jiang

  • 1Department of Surgical Oncology, The Eighty-First Hospital of People's Liberation Army, Nanjing, Jiangsu Province, 210002, China.

Tumour Biology : the Journal of the International Society for Oncodevelopmental Biology and Medicine
|June 5, 2014
PubMed
Summary

This meta-analysis found no significant association between CD24 gene polymorphisms (rs52812045 and rs3838646) and overall cancer risk. However, the rs3838646 polymorphism showed a potential protective effect against breast cancer, though not statistically significant.

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Area of Science:

  • Genetics and Oncology
  • Molecular Biology
  • Cancer Epidemiology

Background:

  • Cluster of differentiation 24 (CD24) is implicated in cancer development.
  • Single nucleotide polymorphisms (SNPs) in the CD24 gene may influence cancer risk.
  • Existing research on CD24 SNPs and cancer susceptibility is conflicting.

Purpose of the Study:

  • To investigate the association between CD24 gene polymorphisms (rs52812045 and rs3838646) and cancer risk.
  • To clarify the conflicting findings regarding CD24 SNPs and cancer susceptibility through a meta-analysis.

Main Methods:

  • A meta-analysis was conducted, pooling data from published case-control studies.
  • Five independent studies comprising 5,539 cancer cases and 10,241 controls were included.
  • Pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were calculated to assess the associations.

Main Results:

  • No significant relationship was found between the studied CD24 SNPs (rs52812045 and rs3838646) and overall cancer risk.
  • A potential protective role for the CD24 rs3838646 polymorphism in breast cancer risk was observed, but it lacked statistical significance.
  • Further analyses for rs3838646 in breast cancer did not reach statistical significance across different genetic models.

Conclusions:

  • The CD24 gene polymorphisms rs52812045 and rs3838646 do not appear to significantly modify overall cancer risk.
  • The rs3838646 polymorphism may have a non-significant protective effect on breast cancer risk.
  • High-quality individual studies are needed to further elucidate the role of these CD24 SNPs in cancer susceptibility.