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A Modified Sonographic Algorithm for Image Acquisition in Life-Threatening Emergencies in the Critically Ill Newborn
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Synovial sarcoma in a premature newborn.

Doğan Köse1, Ali Annagür, Cengiz Erol

  • 1Department of Pediatric Oncology, Selcuk University Faculty of Medicine, Konya, Turkey.

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|June 5, 2014
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Summary

This study reports the youngest infant diagnosed with synovial sarcoma, a rare cancer. The 3-day-old presented with a limb mass and widespread metastases, highlighting the importance of early detection in neonates.

Keywords:
neonatesoft-tissue tumorsynovial sarcoma

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Area of Science:

  • Pediatric Oncology
  • Medical Imaging
  • Histopathology

Background:

  • Synovial sarcoma is uncommon in infants, with most cases occurring in adolescents and young adults.
  • Incidence in infants is approximately 0.5 per million annually.
  • Presentation in children under two years old is exceptionally rare.

Purpose of the Study:

  • To document an extremely rare case of synovial sarcoma in a neonate.
  • To highlight the diagnostic and metastatic potential of this tumor in the youngest reported patient.

Main Methods:

  • Histopathological and immunohistochemical analysis of biopsy material.
  • Whole-body magnetic resonance imaging (WB-MRI) for metastasis detection.

Main Results:

  • Synovial sarcoma confirmed in a 3-day-old male infant with a left arm mass.
  • WB-MRI revealed diffuse metastases in lungs, retroperitoneum, adrenal glands, liver, kidney, and brain.
  • This represents the youngest diagnosed case in existing medical literature.

Conclusions:

  • Synovial sarcoma can occur in neonates, albeit extremely rarely.
  • Early diagnosis and comprehensive staging are crucial due to metastatic potential.
  • This case expands the known age spectrum for synovial sarcoma diagnosis.