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Published on: April 7, 2023
Synovial sarcoma in a premature newborn
Doğan Köse1, Ali Annagür, Cengiz Erol
1Department of Pediatric Oncology, Selcuk University Faculty of Medicine, Konya, Turkey.
Insights
This study reports the youngest infant diagnosed with synovial sarcoma, a rare cancer. The 3-day-old presented with a limb mass and widespread metastases, highlighting the importance of early detection in neonates.
Area of Science:
- Pediatric Oncology
- Medical Imaging
- Histopathology
Background:
- Synovial sarcoma is uncommon in infants, with most cases occurring in adolescents and young adults.
- Incidence in infants is approximately 0.5 per million annually.
- Presentation in children under two years old is exceptionally rare.
Purpose of the Study:
- To document an extremely rare case of synovial sarcoma in a neonate.
- To highlight the diagnostic and metastatic potential of this tumor in the youngest reported patient.
Main Methods:
- Histopathological and immunohistochemical analysis of biopsy material.
- Whole-body magnetic resonance imaging (WB-MRI) for metastasis detection.
Main Results:
- Synovial sarcoma confirmed in a 3-day-old male infant with a left arm mass.
- WB-MRI revealed diffuse metastases in lungs, retroperitoneum, adrenal glands, liver, kidney, and brain.
- This represents the youngest diagnosed case in existing medical literature.
Conclusions:
- Synovial sarcoma can occur in neonates, albeit extremely rarely.
- Early diagnosis and comprehensive staging are crucial due to metastatic potential.
- This case expands the known age spectrum for synovial sarcoma diagnosis.
Abstract:
Synovial sarcoma is rarely detected in infants, with an annual incidence of 0.5 per million. Synovial sarcoma occurs more frequently in adolescents and young adults, with the majority of patients presenting between 15 and 40 years of age. It is extremely rare, however, in pediatric patients under 2 years of age. In the present study we examined a 3-day-old male infant born at 32 weeks who had a mass on his left arm. Synovial sarcoma was identified on histopathological and immunohistochemical analysis of biopsy material acquired from the mass. On whole body magnetic resonance imaging, diffuse metastases were detected in the bilateral lungs in the retroperitoneal zone, in bilateral suprarenal glands, the right liver lobe, the right kidney, and the brain. To our knowledge this is the youngest patient to be diagnosed with synovial sarcoma in the literature.
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